Functional integration of a semi-synthetic azido-queuosine derivative into translation and a tRNA modification circuit

Substitution of the queuine nucleobase precursor preQ(1) by an azide-containing derivative (azido-propyl-preQ(1)) led to incorporation of this clickable chemical entity into tRNA via transglycosylation in vitro as well as in vivo in Escherichia coli, Schizosaccharomyces pombe and human cells. The re...

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Detalles Bibliográficos
Autores principales: Bessler, Larissa, Kaur, Navpreet, Vogt, Lea-Marie, Flemmich, Laurin, Siebenaller, Carmen, Winz, Marie-Luise, Tuorto, Francesca, Micura, Ronald, Ehrenhofer-Murray, Ann E, Helm, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561289/
https://www.ncbi.nlm.nih.gov/pubmed/36169220
http://dx.doi.org/10.1093/nar/gkac822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561289/
https://www.ncbi.nlm.nih.gov/pubmed/36169220
http://dx.doi.org/10.1093/nar/gkac822

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