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Nanopore tweezers measurements of RecQ conformational changes reveal the energy landscape of helicase motion

Helicases are essential for nearly all nucleic acid processes across the tree of life, yet detailed understanding of how they couple ATP hydrolysis to translocation and unwinding remains incomplete because their small (∼300 picometer), fast (∼1 ms) steps are difficult to resolve. Here, we use Nanopo...

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Detalles Bibliográficos
Autores principales:	Craig, Jonathan M, Mills, Maria, Kim, Hwanhee C, Huang, Jesse R, Abell, Sarah J, Mount, Jonathan W, Gundlach, Jens H, Neuman, Keir C, Laszlo, Andrew H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561376/ https://www.ncbi.nlm.nih.gov/pubmed/36165957 http://dx.doi.org/10.1093/nar/gkac837

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