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OCT and OCTA evaluation of vascular and morphological structures in the retina in recovered pediatric patients with COVID-19()
BACKGROUND: Using OCT and OCTA imaging, we aimed to determine whether COVID-19 induces pathological changes in vascular and morphological structures in the pediatric retina. METHODS: The current prospective, cross-sectional, observational clinical study included recovered pediatric patients with COV...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561386/ https://www.ncbi.nlm.nih.gov/pubmed/36244680 http://dx.doi.org/10.1016/j.pdpdt.2022.103157 |
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author | Tiryaki Demir, Semra Dalgic, Nazan Keles Yesiltas, Sumeyra Akbas Ozyurek, Emine Betul Karapapak, Murat Uke Uzun, Saniye Guven, Dilek |
author_facet | Tiryaki Demir, Semra Dalgic, Nazan Keles Yesiltas, Sumeyra Akbas Ozyurek, Emine Betul Karapapak, Murat Uke Uzun, Saniye Guven, Dilek |
author_sort | Tiryaki Demir, Semra |
collection | PubMed |
description | BACKGROUND: Using OCT and OCTA imaging, we aimed to determine whether COVID-19 induces pathological changes in vascular and morphological structures in the pediatric retina. METHODS: The current prospective, cross-sectional, observational clinical study included recovered pediatric patients with COVID-19 evaluated between May 2020 and June 2020. Retinal vascular (radial peripapillary, superficial, and deep capillary plexus vessel densities) and morphological (peripapillary retinal nerve fiber, ganglion cell layer, retinal, and choroidal thickness) in the optic disk and macula regions were quantitively assessed using OCT and OCTA. Data were compared between COVID-19 patients and age-matched controls. RESULTS: The COVID-19 group included 32 eyes of 16 patients and the control group included 32 eyes of 16 cases. Fundus and biomicroscopic examinations revealed no signs of pathology in the COVID-19 group. Mean peripapillary retinal nerve fiber, ganglion cell layer, and choroidal thickness values were significantly greater in the COVID-19 group than in the control group (p<0.05). OCTA indicated that mean superficial and deep capillary plexus vessel densities, and choriocapillaris flow area values were significantly lower in the COVID-19 group than in the control group, whereas mean radial peripapillary capillary plexus vessel density values were significantly higher (p<0.05). CONCLUSIONS: Even if fundus examination results appear normal in pediatric patients with COVID-19, vascular and morphological changes may be observed in the retina. Further studies with larger numbers of patients are needed to elucidate the clinical significance of vascular and morphological changes in this population. |
format | Online Article Text |
id | pubmed-9561386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95613862022-10-16 OCT and OCTA evaluation of vascular and morphological structures in the retina in recovered pediatric patients with COVID-19() Tiryaki Demir, Semra Dalgic, Nazan Keles Yesiltas, Sumeyra Akbas Ozyurek, Emine Betul Karapapak, Murat Uke Uzun, Saniye Guven, Dilek Photodiagnosis Photodyn Ther Article BACKGROUND: Using OCT and OCTA imaging, we aimed to determine whether COVID-19 induces pathological changes in vascular and morphological structures in the pediatric retina. METHODS: The current prospective, cross-sectional, observational clinical study included recovered pediatric patients with COVID-19 evaluated between May 2020 and June 2020. Retinal vascular (radial peripapillary, superficial, and deep capillary plexus vessel densities) and morphological (peripapillary retinal nerve fiber, ganglion cell layer, retinal, and choroidal thickness) in the optic disk and macula regions were quantitively assessed using OCT and OCTA. Data were compared between COVID-19 patients and age-matched controls. RESULTS: The COVID-19 group included 32 eyes of 16 patients and the control group included 32 eyes of 16 cases. Fundus and biomicroscopic examinations revealed no signs of pathology in the COVID-19 group. Mean peripapillary retinal nerve fiber, ganglion cell layer, and choroidal thickness values were significantly greater in the COVID-19 group than in the control group (p<0.05). OCTA indicated that mean superficial and deep capillary plexus vessel densities, and choriocapillaris flow area values were significantly lower in the COVID-19 group than in the control group, whereas mean radial peripapillary capillary plexus vessel density values were significantly higher (p<0.05). CONCLUSIONS: Even if fundus examination results appear normal in pediatric patients with COVID-19, vascular and morphological changes may be observed in the retina. Further studies with larger numbers of patients are needed to elucidate the clinical significance of vascular and morphological changes in this population. Elsevier B.V. 2022-12 2022-10-14 /pmc/articles/PMC9561386/ /pubmed/36244680 http://dx.doi.org/10.1016/j.pdpdt.2022.103157 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Tiryaki Demir, Semra Dalgic, Nazan Keles Yesiltas, Sumeyra Akbas Ozyurek, Emine Betul Karapapak, Murat Uke Uzun, Saniye Guven, Dilek OCT and OCTA evaluation of vascular and morphological structures in the retina in recovered pediatric patients with COVID-19() |
title | OCT and OCTA evaluation of vascular and morphological structures in the retina in recovered pediatric patients with COVID-19() |
title_full | OCT and OCTA evaluation of vascular and morphological structures in the retina in recovered pediatric patients with COVID-19() |
title_fullStr | OCT and OCTA evaluation of vascular and morphological structures in the retina in recovered pediatric patients with COVID-19() |
title_full_unstemmed | OCT and OCTA evaluation of vascular and morphological structures in the retina in recovered pediatric patients with COVID-19() |
title_short | OCT and OCTA evaluation of vascular and morphological structures in the retina in recovered pediatric patients with COVID-19() |
title_sort | oct and octa evaluation of vascular and morphological structures in the retina in recovered pediatric patients with covid-19() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561386/ https://www.ncbi.nlm.nih.gov/pubmed/36244680 http://dx.doi.org/10.1016/j.pdpdt.2022.103157 |
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