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Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality
Since the very beginning of the coronavirus disease 2019 (COVID-19) pandemic in early 2020, it was evident that patients with cardiovascular disease (CVD) were at an increased risk of developing severe illness, and complications spanning cerebrovascular disorders, dysrhythmias, acute coronary syndro...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561478/ https://www.ncbi.nlm.nih.gov/pubmed/36183780 http://dx.doi.org/10.1016/j.lfs.2022.121018 |
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author | Aleksova, Aneta Fluca, Alessandra Lucia Gagno, Giulia Pierri, Alessandro Padoan, Laura Derin, Agnese Moretti, Rita Noveska, Elena Aleksova Azzalini, Eros D'Errico, Stefano Beltrami, Antonio Paolo Zumla, Alimuddin Ippolito, Giuseppe Sinagra, Gianfranco Janjusevic, Milijana |
author_facet | Aleksova, Aneta Fluca, Alessandra Lucia Gagno, Giulia Pierri, Alessandro Padoan, Laura Derin, Agnese Moretti, Rita Noveska, Elena Aleksova Azzalini, Eros D'Errico, Stefano Beltrami, Antonio Paolo Zumla, Alimuddin Ippolito, Giuseppe Sinagra, Gianfranco Janjusevic, Milijana |
author_sort | Aleksova, Aneta |
collection | PubMed |
description | Since the very beginning of the coronavirus disease 2019 (COVID-19) pandemic in early 2020, it was evident that patients with cardiovascular disease (CVD) were at an increased risk of developing severe illness, and complications spanning cerebrovascular disorders, dysrhythmias, acute coronary syndrome, ischemic and non-ischemic heart disease, pericarditis, myocarditis, heart failure, thromboembolic disease, stroke, and death. Underlying these was excessive systemic inflammation and coagulopathy due to SARS-COV-2 infection, the effects of which also continued long-term as evidenced by post-COVID-19 cardiovascular complications. The acute and chronic cardiovascular effects of COVID-19 occurred even among those who were not hospitalized and had no previous CVD or those with mild symptoms. This comprehensive review summarizes the current understanding of molecular mechanisms triggered by the SARS-CoV-2 virus on various cells that express the angiotensin-converting enzyme 2, leading to endothelial dysfunction, inflammation, myocarditis, impaired coagulation, myocardial infarction, arrhythmia and a multisystem inflammatory syndrome in children or Kawasaki-like disease. |
format | Online Article Text |
id | pubmed-9561478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95614782022-10-16 Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality Aleksova, Aneta Fluca, Alessandra Lucia Gagno, Giulia Pierri, Alessandro Padoan, Laura Derin, Agnese Moretti, Rita Noveska, Elena Aleksova Azzalini, Eros D'Errico, Stefano Beltrami, Antonio Paolo Zumla, Alimuddin Ippolito, Giuseppe Sinagra, Gianfranco Janjusevic, Milijana Life Sci Article Since the very beginning of the coronavirus disease 2019 (COVID-19) pandemic in early 2020, it was evident that patients with cardiovascular disease (CVD) were at an increased risk of developing severe illness, and complications spanning cerebrovascular disorders, dysrhythmias, acute coronary syndrome, ischemic and non-ischemic heart disease, pericarditis, myocarditis, heart failure, thromboembolic disease, stroke, and death. Underlying these was excessive systemic inflammation and coagulopathy due to SARS-COV-2 infection, the effects of which also continued long-term as evidenced by post-COVID-19 cardiovascular complications. The acute and chronic cardiovascular effects of COVID-19 occurred even among those who were not hospitalized and had no previous CVD or those with mild symptoms. This comprehensive review summarizes the current understanding of molecular mechanisms triggered by the SARS-CoV-2 virus on various cells that express the angiotensin-converting enzyme 2, leading to endothelial dysfunction, inflammation, myocarditis, impaired coagulation, myocardial infarction, arrhythmia and a multisystem inflammatory syndrome in children or Kawasaki-like disease. Elsevier Inc. 2022-12-01 2022-09-29 /pmc/articles/PMC9561478/ /pubmed/36183780 http://dx.doi.org/10.1016/j.lfs.2022.121018 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Aleksova, Aneta Fluca, Alessandra Lucia Gagno, Giulia Pierri, Alessandro Padoan, Laura Derin, Agnese Moretti, Rita Noveska, Elena Aleksova Azzalini, Eros D'Errico, Stefano Beltrami, Antonio Paolo Zumla, Alimuddin Ippolito, Giuseppe Sinagra, Gianfranco Janjusevic, Milijana Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality |
title | Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality |
title_full | Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality |
title_fullStr | Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality |
title_full_unstemmed | Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality |
title_short | Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality |
title_sort | long-term effect of sars-cov-2 infection on cardiovascular outcomes and all-cause mortality |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561478/ https://www.ncbi.nlm.nih.gov/pubmed/36183780 http://dx.doi.org/10.1016/j.lfs.2022.121018 |
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