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Inflammatory factor tumor necrosis factor-α (TNF-α) activates P-glycoprotein (P-gp) by phosphorylating c-Jun and thus promotes transportation in placental cells

BACKGROUND: P-glycoprotein (P-gp), encoded by the ABCB1 gene, actively pumps drugs and other xenobiotics from trophoblast cells back into the maternal circulation and thus acts as one of the most critical protectors of the fetus. The effect of tumor necrosis factor-α (TNF-α) on P-gp and molecule-tra...

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Detalles Bibliográficos
Autores principales:	Li, Huaying, Yan, Li, Li, Biao, Wei, Guoqing, Ju, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561510/ https://www.ncbi.nlm.nih.gov/pubmed/36247888 http://dx.doi.org/10.21037/tp-22-43

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