Cargando…

Selective vulnerability of ARID1A deficient colon cancer cells to combined radiation and ATR-inhibitor therapy

ARID1A is frequently mutated in colorectal cancer (CRC) cells. Loss of ARID1A function compromises DNA damage repair and increases the reliance of tumor cells on ATR-dependent DNA repair pathways. Here, we investigated the effect of ionizing radiation (IR), in combination with ATR inhibitors (ATRi)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Shan, Sak, Ali, Niedermaier, Ben, Erol, Yasin Bahadir, Groneberg, Michael, Mladenov, Emil, Kang, MingWei, Iliakis, George, Stuschke, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561551/ https://www.ncbi.nlm.nih.gov/pubmed/36249060 http://dx.doi.org/10.3389/fonc.2022.999626

Ejemplares similares

Strong Shift to ATR-Dependent Regulation of the G(2)-Checkpoint after Exposure to High-LET Radiation
por: Mladenova, Veronika, et al.
Publicado: (2021)

Targeting ARID1A-mutant colorectal cancer: depletion of ARID1B increases radiosensitivity and modulates DNA damage response
por: Niedermaier, B., et al.
Publicado: (2019)

The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G(2)-Checkpoint Activation in Cells Exposed to Ionizing Radiation
por: Luo, Daxian, et al.
Publicado: (2023)

Shift in G(1)-Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation
por: Li, Fanghua, et al.
Publicado: (2021)

DNA Damage Clustering after Ionizing Radiation and Consequences in the Processing of Chromatin Breaks
por: Mladenova, Veronika, et al.
Publicado: (2022)

Metformin enhances the radiosensitizing effect of cisplatin in non-small cell lung cancer cell lines with different cisplatin sensitivities
por: Riaz, Muhammad Assad, et al.
Publicado: (2019)

New Facets of DNA Double Strand Break Repair: Radiation Dose as Key Determinant of HR versus c-NHEJ Engagement
por: Mladenov, Emil, et al.
Publicado: (2023)

Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G(2)-phase
por: Mladenov, Emil, et al.
Publicado: (2019)

BMN673 Is a PARP Inhibitor with Unique Radiosensitizing Properties: Mechanisms and Potential in Radiation Therapy
por: Soni, Aashish, et al.
Publicado: (2022)

ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions
por: Soni, Aashish, et al.
Publicado: (2022)

DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G(2)-checkpoint in S-phase irradiated cells
por: Mladenov, Emil, et al.
Publicado: (2019)

The high toxicity of DSB-clusters modelling high-LET-DNA damage derives from inhibition of c-NHEJ and promotion of alt-EJ and SSA despite increases in HR
por: Mladenova, Veronika, et al.
Publicado: (2022)

Network Meta-analysis of First-Line Systemic Treatment for Patients With Metastatic Colorectal Cancer
por: Xu, Shan, et al.
Publicado: (2021)

Increased Gene Targeting in Hyper-Recombinogenic LymphoBlastoid Cell Lines Leaves Unchanged DSB Processing by Homologous Recombination
por: Mladenov, Emil, et al.
Publicado: (2022)

PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination
por: Pei, Xile, et al.
Publicado: (2022)

Novel Biological Approaches for Testing the Contributions of Single DSBs and DSB Clusters to the Biological Effects of High LET Radiation
por: Mladenova, Veronika, et al.
Publicado: (2016)

Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA
por: Krieger, Lisa Marie, et al.
Publicado: (2021)

Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell lines
por: Sak, A, et al.
Publicado: (2005)

Low CDK Activity and Enhanced Degradation by APC/C(CDH1) Abolishes CtIP Activity and Alt-EJ in Quiescent Cells
por: Li, Fanghua, et al.
Publicado: (2023)

DNA Double-Strand Break Repair as Determinant of Cellular Radiosensitivity to Killing and Target in Radiation Therapy
por: Mladenov, Emil, et al.
Publicado: (2013)

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
por: Williamson, Chris T., et al.
Publicado: (2016)

Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer
por: Iliakis, George, et al.
Publicado: (2019)

Targeting the Metabolic Vulnerability of ARID1A-Deficient Hepatocellular Carcinoma
por: Chan, For-Fan, et al.
Publicado: (2022)

Increased Resection at DSBs in G(2)-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ
por: Xiao, Huaping, et al.
Publicado: (2022)

SCF(SKP2) regulates APC/C(CDH1)-mediated degradation of CTIP to adjust DNA-end resection in G(2)-phase
por: Li, Fanghua, et al.
Publicado: (2020)

A consensus set of genetic vulnerabilities to ATR inhibition
por: Hustedt, Nicole, et al.
Publicado: (2019)

ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 While ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition
por: Kurz, Lukas, et al.
Publicado: (2020)

ARID1B is a specific vulnerability in ARID1A-mutant cancers
por: Helming, Katherine C., et al.
Publicado: (2014)

Therapeutic Vulnerability to ATR Inhibition in Concurrent NF1 and ATRX-Deficient/ALT-Positive High-Grade Solid Tumors
por: Yuan, Ming, et al.
Publicado: (2022)

Habitat selection by vulnerable golden bandicoots in the arid zone
por: Lohr, Cheryl A., et al.
Publicado: (2021)

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
por: Menolfi, Demis, et al.
Publicado: (2018)

ATR represents a therapeutic vulnerability in clear cell renal cell carcinoma
por: Seidel, Philipp, et al.
Publicado: (2022)

Clonality disguises the vulnerability of a threatened arid zone Acacia
por: Roberts, David G., et al.
Publicado: (2017)

Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment
por: Schipler, Agnes, et al.
Publicado: (2016)

Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52
por: Mladenov, Emil, et al.
Publicado: (2020)

Dual blockade of BRD4 and ATR/WEE1 pathways exploits ARID1A loss in clear cell ovarian cancer
por: Kinose, Yasuto, et al.
Publicado: (2023)

"ATR activation in response to ionizing radiation: still ATM territory"
por: Cuadrado, Myriam, et al.
Publicado: (2006)

Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions
por: Singh, Satyendra K, et al.
Publicado: (2013)

Chemical Inhibition of RPA by HAMNO Alters Cell Cycle Dynamics by Impeding DNA Replication and G2-to-M Transition but Has Little Effect on the Radiation-Induced DNA Damage Response
por: Dueva, Rositsa, et al.
Publicado: (2023)

Identification of the First ATRIP–Deficient Patient and Novel Mutations in ATR Define a Clinical Spectrum for ATR–ATRIP Seckel Syndrome
por: Ogi, Tomoo, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_gtfq41o3b4uvv7puuri07k7614