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Selective vulnerability of ARID1A deficient colon cancer cells to combined radiation and ATR-inhibitor therapy

ARID1A is frequently mutated in colorectal cancer (CRC) cells. Loss of ARID1A function compromises DNA damage repair and increases the reliance of tumor cells on ATR-dependent DNA repair pathways. Here, we investigated the effect of ionizing radiation (IR), in combination with ATR inhibitors (ATRi)...

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Detalles Bibliográficos
Autores principales:	Xu, Shan, Sak, Ali, Niedermaier, Ben, Erol, Yasin Bahadir, Groneberg, Michael, Mladenov, Emil, Kang, MingWei, Iliakis, George, Stuschke, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561551/ https://www.ncbi.nlm.nih.gov/pubmed/36249060 http://dx.doi.org/10.3389/fonc.2022.999626

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