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Chemotherapy, transarterial chemoembolization, and nephrectomy combined treated one giant renal cell carcinoma (T3aN1M1) associated with Xp11.2/TFE3: A case report

BACKGROUND: Renal cell carcinoma (RCC) with Xp11.2 translocation/TFE3 gene fusion is a rare and distinct subtype of RCC that is classified under tumors with translocation of the microphthalmia-associated transcriptional factor. CASE SUMMARY: We report an adult case of Xp11.2 translocation advanced R...

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Autores principales: Wang, Peng, Zhang, Xiao, Shao, Shuo-Han, Wu, Fa, Du, Fei-Zhou, Zhang, Jun-Feng, Zuo, Zhi-Way, Jiang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561562/
https://www.ncbi.nlm.nih.gov/pubmed/36246795
http://dx.doi.org/10.12998/wjcc.v10.i28.10180
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author Wang, Peng
Zhang, Xiao
Shao, Shuo-Han
Wu, Fa
Du, Fei-Zhou
Zhang, Jun-Feng
Zuo, Zhi-Way
Jiang, Rui
author_facet Wang, Peng
Zhang, Xiao
Shao, Shuo-Han
Wu, Fa
Du, Fei-Zhou
Zhang, Jun-Feng
Zuo, Zhi-Way
Jiang, Rui
author_sort Wang, Peng
collection PubMed
description BACKGROUND: Renal cell carcinoma (RCC) with Xp11.2 translocation/TFE3 gene fusion is a rare and distinct subtype of RCC that is classified under tumors with translocation of the microphthalmia-associated transcriptional factor. CASE SUMMARY: We report an adult case of Xp11.2 translocation advanced RCC with metastasis (T3aN1M1), after targeted treatment, alcohol ablation, and transarterial chemoembolization, who eventually underwent successful surgical excision. No recurrence or transfer was seen within one year, and the survival period was more than 3 years. A review of the relevant literature was conducted to improve our understanding of the pathogenesis, epidemiology, clinical manifestations, diagnosis, differential diagnosis, treatment, and other aspects of the disease. CONCLUSION: Transarterial chemoembolization and ablation did not achieve the desired tumor reduction in this patient, but had a significant effect on reducing intraoperative bleeding and inhibiting tumor activity.
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spelling pubmed-95615622022-10-15 Chemotherapy, transarterial chemoembolization, and nephrectomy combined treated one giant renal cell carcinoma (T3aN1M1) associated with Xp11.2/TFE3: A case report Wang, Peng Zhang, Xiao Shao, Shuo-Han Wu, Fa Du, Fei-Zhou Zhang, Jun-Feng Zuo, Zhi-Way Jiang, Rui World J Clin Cases Case Report BACKGROUND: Renal cell carcinoma (RCC) with Xp11.2 translocation/TFE3 gene fusion is a rare and distinct subtype of RCC that is classified under tumors with translocation of the microphthalmia-associated transcriptional factor. CASE SUMMARY: We report an adult case of Xp11.2 translocation advanced RCC with metastasis (T3aN1M1), after targeted treatment, alcohol ablation, and transarterial chemoembolization, who eventually underwent successful surgical excision. No recurrence or transfer was seen within one year, and the survival period was more than 3 years. A review of the relevant literature was conducted to improve our understanding of the pathogenesis, epidemiology, clinical manifestations, diagnosis, differential diagnosis, treatment, and other aspects of the disease. CONCLUSION: Transarterial chemoembolization and ablation did not achieve the desired tumor reduction in this patient, but had a significant effect on reducing intraoperative bleeding and inhibiting tumor activity. Baishideng Publishing Group Inc 2022-10-06 2022-10-06 /pmc/articles/PMC9561562/ /pubmed/36246795 http://dx.doi.org/10.12998/wjcc.v10.i28.10180 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Wang, Peng
Zhang, Xiao
Shao, Shuo-Han
Wu, Fa
Du, Fei-Zhou
Zhang, Jun-Feng
Zuo, Zhi-Way
Jiang, Rui
Chemotherapy, transarterial chemoembolization, and nephrectomy combined treated one giant renal cell carcinoma (T3aN1M1) associated with Xp11.2/TFE3: A case report
title Chemotherapy, transarterial chemoembolization, and nephrectomy combined treated one giant renal cell carcinoma (T3aN1M1) associated with Xp11.2/TFE3: A case report
title_full Chemotherapy, transarterial chemoembolization, and nephrectomy combined treated one giant renal cell carcinoma (T3aN1M1) associated with Xp11.2/TFE3: A case report
title_fullStr Chemotherapy, transarterial chemoembolization, and nephrectomy combined treated one giant renal cell carcinoma (T3aN1M1) associated with Xp11.2/TFE3: A case report
title_full_unstemmed Chemotherapy, transarterial chemoembolization, and nephrectomy combined treated one giant renal cell carcinoma (T3aN1M1) associated with Xp11.2/TFE3: A case report
title_short Chemotherapy, transarterial chemoembolization, and nephrectomy combined treated one giant renal cell carcinoma (T3aN1M1) associated with Xp11.2/TFE3: A case report
title_sort chemotherapy, transarterial chemoembolization, and nephrectomy combined treated one giant renal cell carcinoma (t3an1m1) associated with xp11.2/tfe3: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561562/
https://www.ncbi.nlm.nih.gov/pubmed/36246795
http://dx.doi.org/10.12998/wjcc.v10.i28.10180
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