Tislelizumab-related enteritis successfully treated with adalimumab: A case report

BACKGROUND: With programmed death-1 (PD-1) inhibitors becoming the standard treatment for lung cancer, PD-1-related adverse reactions and treatment have gradually become prominent. CASE SUMMARY: First reported case of tislelizumab-related enteritis successfully treated with adalimumab 40mg every 2 w...

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Autores principales: Chen, Na, Qian, Min-Jia, Zhang, Ru-Hui, Gao, Qi-Qi, He, Chao-Chao, Yao, Ya-Ke, Zhou, Jian-Ying, Zhou, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561571/
https://www.ncbi.nlm.nih.gov/pubmed/36246838
http://dx.doi.org/10.12998/wjcc.v10.i28.10186
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author Chen, Na
Qian, Min-Jia
Zhang, Ru-Hui
Gao, Qi-Qi
He, Chao-Chao
Yao, Ya-Ke
Zhou, Jian-Ying
Zhou, Hua
author_facet Chen, Na
Qian, Min-Jia
Zhang, Ru-Hui
Gao, Qi-Qi
He, Chao-Chao
Yao, Ya-Ke
Zhou, Jian-Ying
Zhou, Hua
author_sort Chen, Na
collection PubMed
description BACKGROUND: With programmed death-1 (PD-1) inhibitors becoming the standard treatment for lung cancer, PD-1-related adverse reactions and treatment have gradually become prominent. CASE SUMMARY: First reported case of tislelizumab-related enteritis successfully treated with adalimumab 40mg every 2 wk for 3 times in an advanced lung cancer patient who received first-line tislelizumab/pemetrexed/carboplatin for 4 cycles. The patient continued receiving the treatment of pemetrexed/carboplatin after symptoms, abdominal computed tomography and colonoscopy improved, significant diarrhea was not occurred. CONCLUSION: Adalimumab can be an effective treatment option for patients with PD-1 antibody related enteritis if they do not respond well to glucocorticoid treatment.
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spelling pubmed-95615712022-10-15 Tislelizumab-related enteritis successfully treated with adalimumab: A case report Chen, Na Qian, Min-Jia Zhang, Ru-Hui Gao, Qi-Qi He, Chao-Chao Yao, Ya-Ke Zhou, Jian-Ying Zhou, Hua World J Clin Cases Case Report BACKGROUND: With programmed death-1 (PD-1) inhibitors becoming the standard treatment for lung cancer, PD-1-related adverse reactions and treatment have gradually become prominent. CASE SUMMARY: First reported case of tislelizumab-related enteritis successfully treated with adalimumab 40mg every 2 wk for 3 times in an advanced lung cancer patient who received first-line tislelizumab/pemetrexed/carboplatin for 4 cycles. The patient continued receiving the treatment of pemetrexed/carboplatin after symptoms, abdominal computed tomography and colonoscopy improved, significant diarrhea was not occurred. CONCLUSION: Adalimumab can be an effective treatment option for patients with PD-1 antibody related enteritis if they do not respond well to glucocorticoid treatment. Baishideng Publishing Group Inc 2022-10-06 2022-10-06 /pmc/articles/PMC9561571/ /pubmed/36246838 http://dx.doi.org/10.12998/wjcc.v10.i28.10186 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Chen, Na
Qian, Min-Jia
Zhang, Ru-Hui
Gao, Qi-Qi
He, Chao-Chao
Yao, Ya-Ke
Zhou, Jian-Ying
Zhou, Hua
Tislelizumab-related enteritis successfully treated with adalimumab: A case report
title Tislelizumab-related enteritis successfully treated with adalimumab: A case report
title_full Tislelizumab-related enteritis successfully treated with adalimumab: A case report
title_fullStr Tislelizumab-related enteritis successfully treated with adalimumab: A case report
title_full_unstemmed Tislelizumab-related enteritis successfully treated with adalimumab: A case report
title_short Tislelizumab-related enteritis successfully treated with adalimumab: A case report
title_sort tislelizumab-related enteritis successfully treated with adalimumab: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561571/
https://www.ncbi.nlm.nih.gov/pubmed/36246838
http://dx.doi.org/10.12998/wjcc.v10.i28.10186
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