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Factors affecting the changes in antihypertensive medications in patients with hypertension

As frequent changes in anti-hypertensive (HTN) medications may reduce adherence to the treatments, identifying modifiable factors leading to changes in anti-HTN medications can help clinicians optimize treatment strategies for individual patients. We performed this study to explore the pattern of an...

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Autores principales: Chung, Tae Kyu, Jeon, Yoomin, Hong, YeSol, Hong, Suyeon, Moon, Jun Sik, Lee, Howard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561640/
https://www.ncbi.nlm.nih.gov/pubmed/36247446
http://dx.doi.org/10.3389/fcvm.2022.999548
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author Chung, Tae Kyu
Jeon, Yoomin
Hong, YeSol
Hong, Suyeon
Moon, Jun Sik
Lee, Howard
author_facet Chung, Tae Kyu
Jeon, Yoomin
Hong, YeSol
Hong, Suyeon
Moon, Jun Sik
Lee, Howard
author_sort Chung, Tae Kyu
collection PubMed
description As frequent changes in anti-hypertensive (HTN) medications may reduce adherence to the treatments, identifying modifiable factors leading to changes in anti-HTN medications can help clinicians optimize treatment strategies for individual patients. We performed this study to explore the pattern of anti-HTN medications and to identify factors that are associated with the changes in anti-HTN medications. To this end, we used a clinical database of Seoul National University Hospital, extracted, transformed, and loaded by the observational medical outcomes partnership common data model. Demographic and all recorded clinical diagnoses, medications, and procedures data of eligible subjects were collected. Of 636 subjects who were eligible for this study, 297 subjects with a record of ≥1 anti-HTN medication changes and other 297 subjects without a record of medication change were selected for the study population. High diastolic blood pressure (adjusted odds ratio [OR]: 1.02, 95% confidence interval [CI]: 1.001–1.040, p = 0.040), arrhythmia (adjusted OR: 10.01, 95% CI: 1.86–185.57, p = 0.030), and angina pectoris with antianginal agents (adjusted OR: 4.85, CI: 1.05–23.89, p = 0.046) were associated with the changes in anti-HTN medications, indicating that any patients with these covariates require additional attention to reduce the likelihood of changing anti-HTN medications.
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spelling pubmed-95616402022-10-15 Factors affecting the changes in antihypertensive medications in patients with hypertension Chung, Tae Kyu Jeon, Yoomin Hong, YeSol Hong, Suyeon Moon, Jun Sik Lee, Howard Front Cardiovasc Med Cardiovascular Medicine As frequent changes in anti-hypertensive (HTN) medications may reduce adherence to the treatments, identifying modifiable factors leading to changes in anti-HTN medications can help clinicians optimize treatment strategies for individual patients. We performed this study to explore the pattern of anti-HTN medications and to identify factors that are associated with the changes in anti-HTN medications. To this end, we used a clinical database of Seoul National University Hospital, extracted, transformed, and loaded by the observational medical outcomes partnership common data model. Demographic and all recorded clinical diagnoses, medications, and procedures data of eligible subjects were collected. Of 636 subjects who were eligible for this study, 297 subjects with a record of ≥1 anti-HTN medication changes and other 297 subjects without a record of medication change were selected for the study population. High diastolic blood pressure (adjusted odds ratio [OR]: 1.02, 95% confidence interval [CI]: 1.001–1.040, p = 0.040), arrhythmia (adjusted OR: 10.01, 95% CI: 1.86–185.57, p = 0.030), and angina pectoris with antianginal agents (adjusted OR: 4.85, CI: 1.05–23.89, p = 0.046) were associated with the changes in anti-HTN medications, indicating that any patients with these covariates require additional attention to reduce the likelihood of changing anti-HTN medications. Frontiers Media S.A. 2022-09-30 /pmc/articles/PMC9561640/ /pubmed/36247446 http://dx.doi.org/10.3389/fcvm.2022.999548 Text en Copyright © 2022 Chung, Jeon, Hong, Hong, Moon and Lee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Chung, Tae Kyu
Jeon, Yoomin
Hong, YeSol
Hong, Suyeon
Moon, Jun Sik
Lee, Howard
Factors affecting the changes in antihypertensive medications in patients with hypertension
title Factors affecting the changes in antihypertensive medications in patients with hypertension
title_full Factors affecting the changes in antihypertensive medications in patients with hypertension
title_fullStr Factors affecting the changes in antihypertensive medications in patients with hypertension
title_full_unstemmed Factors affecting the changes in antihypertensive medications in patients with hypertension
title_short Factors affecting the changes in antihypertensive medications in patients with hypertension
title_sort factors affecting the changes in antihypertensive medications in patients with hypertension
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561640/
https://www.ncbi.nlm.nih.gov/pubmed/36247446
http://dx.doi.org/10.3389/fcvm.2022.999548
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