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PI3Kβ-regulated β-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression

The mechanism governing the transition of human embryonic stem cells (hESCs) toward differentiated cells is only partially understood. To explore this transition, the activity and expression of the ubiquitous phosphatidylinositol 3-kinase (PI3Kα and PI3Kβ) were modulated in primed hESCs. The study r...

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Detalles Bibliográficos
Autores principales:	Yadav, Sudhanshu, Garrido, Antonio, Hernández, M. Carmen, Oliveros, Juan C., Pérez-García, Vicente, Fraga, Mario F., Carrera, Ana C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561645/ https://www.ncbi.nlm.nih.gov/pubmed/36179694 http://dx.doi.org/10.1016/j.stemcr.2022.09.003

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