c-Mpl-del, a c-Mpl alternative splicing isoform, promotes AMKL progression and chemoresistance

Acute megakaryocytic leukemia (AMKL) is a clinically heterogeneous subtype of acute myeloid leukemia characterized by unrestricted megakaryoblast proliferation and poor prognosis. Thrombopoietin receptor c-Mpl is a primary regulator of megakaryopoeisis and a potent mitogenic receptor. Aberrant c-Mpl...

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Detalles Bibliográficos
Autores principales: Li, Fei, Xiong, Yuanyan, Yang, Mo, Chen, Peiling, Zhang, Jingkai, Wang, Qiong, Xu, Miao, Wang, Yiming, He, Zuyong, Zhao, Xin, Huang, Junyu, Gu, Xiaoqiong, Zhang, Li, Sun, Rui, Sun, Xunsha, Li, Jingyao, Ou, Jinxin, Xu, Ting, Huang, Xueying, Cao, Yange, Xu, Xiaohong Ruby, Karakas, Danielle, Li, June, Ni, Heyu, Zhang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561678/
https://www.ncbi.nlm.nih.gov/pubmed/36229456
http://dx.doi.org/10.1038/s41419-022-05315-5

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