MED1, a novel binding partner of BRCA1, regulates homologous recombination and R-loop processing

Homologous recombination (HR) is a major repair pathway of DNA double-strand breaks and is closely related to carcinogenesis. HR deficiency has been established as a therapeutic target. The aim of this study was to elucidate the functions of a novel HR factor, Mediator complex subunit 1 (MED1), and...

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Detalles Bibliográficos
Autores principales: Honjoh, Harunori, Tanikawa, Michihiro, Wada-Hiraike, Osamu, Oda, Katsutoshi, Inaba, Hirofumi, Kukita, Asako, Kawata, Yoshiko, Kusakabe, Misako, Tsuchimochi, Saki, Taguchi, Ayumi, Miyamoto, Yuichiro, Sone, Kenbun, Tsuruga, Tetsushi, Mori-Uchino, Mayuyo, Matsumoto, Yoko, Osuga, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561711/
https://www.ncbi.nlm.nih.gov/pubmed/36229463
http://dx.doi.org/10.1038/s41598-022-21495-8

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