Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy

The retinal pigment epithelium (RPE) plays an important role in the development of diabetic retinopathy (DR), a leading cause of blindness worldwide. Here we set out to explore the role of Akt2 signaling—integral to both RPE homeostasis and glucose metabolism—to DR. Using human tissue and geneticall...

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Detalles Bibliográficos
Autores principales: Liu, Haitao, Stepicheva, Nadezda A., Ghosh, Sayan, Shang, Peng, Chowdhury, Olivia, Daley, Rachel A., Yazdankhah, Meysam, Gupta, Urvi, Hose, Stacey L., Valapala, Mallika, Fitting, Christopher Scott, Strizhakova, Anastasia, Shan, Yang, Feenstra, Derrick, Sahel, José-Alain, Jayagopal, Ashwath, Handa, James T., Zigler, J. Samuel, Fort, Patrice E., Sodhi, Akrit, Sinha, Debasish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561713/
https://www.ncbi.nlm.nih.gov/pubmed/36229454
http://dx.doi.org/10.1038/s41467-022-33773-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561713/
https://www.ncbi.nlm.nih.gov/pubmed/36229454
http://dx.doi.org/10.1038/s41467-022-33773-0

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