Cargando…

Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy

The retinal pigment epithelium (RPE) plays an important role in the development of diabetic retinopathy (DR), a leading cause of blindness worldwide. Here we set out to explore the role of Akt2 signaling—integral to both RPE homeostasis and glucose metabolism—to DR. Using human tissue and geneticall...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Haitao, Stepicheva, Nadezda A., Ghosh, Sayan, Shang, Peng, Chowdhury, Olivia, Daley, Rachel A., Yazdankhah, Meysam, Gupta, Urvi, Hose, Stacey L., Valapala, Mallika, Fitting, Christopher Scott, Strizhakova, Anastasia, Shan, Yang, Feenstra, Derrick, Sahel, José-Alain, Jayagopal, Ashwath, Handa, James T., Zigler, J. Samuel, Fort, Patrice E., Sodhi, Akrit, Sinha, Debasish
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561713/ https://www.ncbi.nlm.nih.gov/pubmed/36229454 http://dx.doi.org/10.1038/s41467-022-33773-0

Ejemplares similares

βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells
por: Shang, Peng, et al.
Publicado: (2021)

The role of lipocalin-2 in age-related macular degeneration (AMD)
por: Ghosh, Sayan, et al.
Publicado: (2020)

A Novel Method of Mouse RPE Explant Culture and Effective Introduction of Transgenes Using Adenoviral Transduction for In Vitro Studies in AMD
por: Shang, Peng, et al.
Publicado: (2021)

Mitophagy in Astrocytes Is Required for the Health of Optic Nerve
por: Yazdankhah, Meysam, et al.
Publicado: (2023)

βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity
por: Ghosh, Sayan, et al.
Publicado: (2021)

Aberrant Akt2 signaling in the RPE may contribute to retinal fibrosis process in diabetic retinopathy
por: Daley, Rachel, et al.
Publicado: (2023)

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration
por: Ghosh, Sayan, et al.
Publicado: (2018)

Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy
por: Liu, Haitao, et al.
Publicado: (2023)

Neutrophils homing into the retina trigger pathology in early age-related macular degeneration
por: Ghosh, Sayan, et al.
Publicado: (2019)

βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes
por: Valapala, Mallika, et al.
Publicado: (2015)

The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling
por: Shang, Peng, et al.
Publicado: (2017)

Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response
por: Valapala, Mallika, et al.
Publicado: (2014)

βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis
por: Ma, B, et al.
Publicado: (2011)

Microglia–Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model
por: Boyce, Maeve, et al.
Publicado: (2022)

Compensatory growth in novel Drosophila Akt1 mutants
por: Slade, Jennifer D, et al.
Publicado: (2015)

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling
por: Valapala, Mallika, et al.
Publicado: (2014)

Role of the Transcriptional Repressor Zinc Finger with KRAB and SCAN Domains 3 (ZKSCAN3) in Retinal Pigment Epithelial Cells
por: Pan, Hsuan-Yeh, et al.
Publicado: (2021)

Regulation of Autophagy by the Glycogen Synthase Kinase-3 (GSK-3) Signaling Pathway
por: Pan, Hsuan-Yeh, et al.
Publicado: (2022)

Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells
por: Bokobza, Sivan M., et al.
Publicado: (2014)

Nutrient deprivation and lysosomal stress induce activation of TFEB in retinal pigment epithelial cells
por: Pan, Hsuan-Yeh, et al.
Publicado: (2019)

The Role of the Immune Response in Age-Related Macular Degeneration
por: Whitcup, Scott M., et al.
Publicado: (2013)

PI3K/AKT inhibition induces compensatory activation of the MET/STAT3 pathway in non-small cell lung cancer
por: Bian, Chunan, et al.
Publicado: (2018)

All Akt Isoforms (Akt1, Akt2, Akt3) Are Involved in Normal Hearing, but Only Akt2 and Akt3 Are Involved in Auditory Hair Cell Survival in the Mammalian Inner Ear
por: Brand, Yves, et al.
Publicado: (2015)

Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk
por: Tamaskovic, Rastislav, et al.
Publicado: (2016)

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer
por: Butler, Dominika E., et al.
Publicado: (2017)

Akt Is S-Palmitoylated: A New Layer of Regulation for Akt
por: Blaustein, Matías, et al.
Publicado: (2021)

Role of Nuclear Factor of Activated T Cells (NFAT) Pathway in Regulating Autophagy and Inflammation in Retinal Pigment Epithelial Cells
por: Pan, Hsuan-Yeh, et al.
Publicado: (2021)

PI3K/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells
por: Maharati, Amirhosein, et al.
Publicado: (2023)

Expression and localisation of Akt-1, Akt-2 and Akt-3 correlate with clinical outcome of prostate cancer patients
por: Le Page, C, et al.
Publicado: (2006)

In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO)
por: Uddin, Md. Imam, et al.
Publicado: (2017)

Compensatory Upregulation of LPA(2) and Activation of the PI3K-Akt Pathway Prevent LPA(5)-Dependent Loss of Intestinal Epithelial Cells in Intestinal Organoids
por: Liang, Zhongxing, et al.
Publicado: (2022)

Akt destabilizes p57(Kip2): Akt at the converging crossroad?
por: Lo, Hui-Wen
Publicado: (2013)

AKT2 is the predominant AKT isoform expressed in human skeletal muscle
por: Matheny, Ronald W., et al.
Publicado: (2018)

Brown fat organogenesis and maintenance requires AKT1 and AKT2
por: Sanchez-Gurmaches, Joan, et al.
Publicado: (2019)

Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092
por: Yu, Yi, et al.
Publicado: (2015)

Akt in the pathogenesis of COPD
por: Bozinovski, Steven, et al.
Publicado: (2006)

Akt-Girdin as oncotarget
por: Takahashi, Masahide, et al.
Publicado: (2015)

Drosophila eugracilis – Akt
por: Morgan, Ashley, et al.
Publicado: (2022)

Getting the Akt Together: Guiding Intracellular Akt Activity by PI3K
por: Yudushkin, Ivan
Publicado: (2019)

Akt methylation by SETDB1 promotes Akt kinase activity and oncogenic functions
por: Guo, Jianping, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_h1ihq4pla1m60223piafctj6ji