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Debonding‐On‐Demand Polymeric Wound Patches for Minimal Adhesion and Clinical Communication

Herein, a multifunctional bilayer wound patch is developed by integrating a debonding‐on‐demand polymeric tissue adhesive (DDPTA) with an ionic conducting elastomer (ICE). As a skin adhesive layer, the DDPTA is soft and adherent at skin temperature but hard and non‐tacky when cooled, so it provides...

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Autores principales: Zeng, Qiankun, Wang, Fangbing, Hu, Ruixuan, Ding, Xuyin, Lu, Yifan, Shi, Guoyue, Haick, Hossam, Zhang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561782/
https://www.ncbi.nlm.nih.gov/pubmed/35988152
http://dx.doi.org/10.1002/advs.202202635
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author Zeng, Qiankun
Wang, Fangbing
Hu, Ruixuan
Ding, Xuyin
Lu, Yifan
Shi, Guoyue
Haick, Hossam
Zhang, Min
author_facet Zeng, Qiankun
Wang, Fangbing
Hu, Ruixuan
Ding, Xuyin
Lu, Yifan
Shi, Guoyue
Haick, Hossam
Zhang, Min
author_sort Zeng, Qiankun
collection PubMed
description Herein, a multifunctional bilayer wound patch is developed by integrating a debonding‐on‐demand polymeric tissue adhesive (DDPTA) with an ionic conducting elastomer (ICE). As a skin adhesive layer, the DDPTA is soft and adherent at skin temperature but hard and non‐tacky when cooled, so it provides unique temperature‐triggered quick adhesion and non‐forced detachment from the skin. During use, the dense surface of the DDPTA prevents blood infiltration and reduces unnecessary blood loss with gentle pressing. Moreover, its hydrophobic matrix helps to repel blood and prevents the formation of clots, thus precluding wound tearing during its removal. This unique feature enables the DDPTA to avoid the severe deficiencies of hydrophilic adhesives, providing a reliable solution for a wide range of secondary wound injuries. The DDPTA is versatile in that it can be covered with ICE to configure a DDPTA@ICE patch for initiating non‐verbal communication systems by the fingers, leading toward sign language recognition and a remote clinical alarm system. This multifunctional wound patch with debonding‐on‐demand can promote a new style of tissue sealant for convenient clinical communication.
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spelling pubmed-95617822022-10-16 Debonding‐On‐Demand Polymeric Wound Patches for Minimal Adhesion and Clinical Communication Zeng, Qiankun Wang, Fangbing Hu, Ruixuan Ding, Xuyin Lu, Yifan Shi, Guoyue Haick, Hossam Zhang, Min Adv Sci (Weinh) Research Articles Herein, a multifunctional bilayer wound patch is developed by integrating a debonding‐on‐demand polymeric tissue adhesive (DDPTA) with an ionic conducting elastomer (ICE). As a skin adhesive layer, the DDPTA is soft and adherent at skin temperature but hard and non‐tacky when cooled, so it provides unique temperature‐triggered quick adhesion and non‐forced detachment from the skin. During use, the dense surface of the DDPTA prevents blood infiltration and reduces unnecessary blood loss with gentle pressing. Moreover, its hydrophobic matrix helps to repel blood and prevents the formation of clots, thus precluding wound tearing during its removal. This unique feature enables the DDPTA to avoid the severe deficiencies of hydrophilic adhesives, providing a reliable solution for a wide range of secondary wound injuries. The DDPTA is versatile in that it can be covered with ICE to configure a DDPTA@ICE patch for initiating non‐verbal communication systems by the fingers, leading toward sign language recognition and a remote clinical alarm system. This multifunctional wound patch with debonding‐on‐demand can promote a new style of tissue sealant for convenient clinical communication. John Wiley and Sons Inc. 2022-08-21 /pmc/articles/PMC9561782/ /pubmed/35988152 http://dx.doi.org/10.1002/advs.202202635 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Zeng, Qiankun
Wang, Fangbing
Hu, Ruixuan
Ding, Xuyin
Lu, Yifan
Shi, Guoyue
Haick, Hossam
Zhang, Min
Debonding‐On‐Demand Polymeric Wound Patches for Minimal Adhesion and Clinical Communication
title Debonding‐On‐Demand Polymeric Wound Patches for Minimal Adhesion and Clinical Communication
title_full Debonding‐On‐Demand Polymeric Wound Patches for Minimal Adhesion and Clinical Communication
title_fullStr Debonding‐On‐Demand Polymeric Wound Patches for Minimal Adhesion and Clinical Communication
title_full_unstemmed Debonding‐On‐Demand Polymeric Wound Patches for Minimal Adhesion and Clinical Communication
title_short Debonding‐On‐Demand Polymeric Wound Patches for Minimal Adhesion and Clinical Communication
title_sort debonding‐on‐demand polymeric wound patches for minimal adhesion and clinical communication
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561782/
https://www.ncbi.nlm.nih.gov/pubmed/35988152
http://dx.doi.org/10.1002/advs.202202635
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