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Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response
Background: The guanylate-binding proteins (GBPs) are the latest potential targets of immunotherapy. However, the role of GBP5 in pan-cancer, including colorectal cancer (CRC), remains unclear. This study aims to explore the effect of GBP5 on immunity in pan-cancer. Methods: Based on the RNA sequenc...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561824/ https://www.ncbi.nlm.nih.gov/pubmed/36246628 http://dx.doi.org/10.3389/fgene.2022.984615 |
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author | Li, Xiang Song, Dan Su, Song He, Xiaobo Cao, Fengyu Yang, Chao Li, Kai Huang, Shuoyang Li, Changhua Wang, Chenhong Zhang, Aikang Pang, Pengcheng Zheng, Yongbin |
author_facet | Li, Xiang Song, Dan Su, Song He, Xiaobo Cao, Fengyu Yang, Chao Li, Kai Huang, Shuoyang Li, Changhua Wang, Chenhong Zhang, Aikang Pang, Pengcheng Zheng, Yongbin |
author_sort | Li, Xiang |
collection | PubMed |
description | Background: The guanylate-binding proteins (GBPs) are the latest potential targets of immunotherapy. However, the role of GBP5 in pan-cancer, including colorectal cancer (CRC), remains unclear. This study aims to explore the effect of GBP5 on immunity in pan-cancer. Methods: Based on the RNA sequencing data of 33 cancers obtained from The Cancer Genome Atlas, we analyzed the clinical significance of GBPs and focused on the correlation between GBP5 and tumor microenvironment (TME). Immunotherapy cohort IMvigor210 was used to explore the relationship between treatment response and GBPs. Then, we further analyzed the expression of GBP5 in immune cells using single-cell transcriptome cohort GSE146771 and GSE132465 from the Gene Expression Omnibus database. Finally, a prognostic model based on GBP5 expression was established and validated. Results: We found that the expression of GBP3/4/5 is higher in colorectal cancer than in normal tissues, and GBP5 is a better predictor of good treatment response to immune checkpoint blockade than other GBPs. In most other cancers, GBP5 is also elevated in tumors compared with normal tissues and is associated with a better prognosis. As for TME, GBP5 is generally positively correlated with immune score, the level of tumor-infiltrating immune cells and immune-related genes. Single-cell analysis showed that GBP5 was mainly expressed in myeloid cells and T cells. The GBP5-related prognostic model we constructed in CRC can predict the survival of patients and propose some genes for subsequent research. Conclusion: This study revealed a strong correlation between GBP5 and immunity in generalized cancer and provided evidence that CRC may be a suitable cancer type for anti-GBP5 therapy. |
format | Online Article Text |
id | pubmed-9561824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95618242022-10-15 Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response Li, Xiang Song, Dan Su, Song He, Xiaobo Cao, Fengyu Yang, Chao Li, Kai Huang, Shuoyang Li, Changhua Wang, Chenhong Zhang, Aikang Pang, Pengcheng Zheng, Yongbin Front Genet Genetics Background: The guanylate-binding proteins (GBPs) are the latest potential targets of immunotherapy. However, the role of GBP5 in pan-cancer, including colorectal cancer (CRC), remains unclear. This study aims to explore the effect of GBP5 on immunity in pan-cancer. Methods: Based on the RNA sequencing data of 33 cancers obtained from The Cancer Genome Atlas, we analyzed the clinical significance of GBPs and focused on the correlation between GBP5 and tumor microenvironment (TME). Immunotherapy cohort IMvigor210 was used to explore the relationship between treatment response and GBPs. Then, we further analyzed the expression of GBP5 in immune cells using single-cell transcriptome cohort GSE146771 and GSE132465 from the Gene Expression Omnibus database. Finally, a prognostic model based on GBP5 expression was established and validated. Results: We found that the expression of GBP3/4/5 is higher in colorectal cancer than in normal tissues, and GBP5 is a better predictor of good treatment response to immune checkpoint blockade than other GBPs. In most other cancers, GBP5 is also elevated in tumors compared with normal tissues and is associated with a better prognosis. As for TME, GBP5 is generally positively correlated with immune score, the level of tumor-infiltrating immune cells and immune-related genes. Single-cell analysis showed that GBP5 was mainly expressed in myeloid cells and T cells. The GBP5-related prognostic model we constructed in CRC can predict the survival of patients and propose some genes for subsequent research. Conclusion: This study revealed a strong correlation between GBP5 and immunity in generalized cancer and provided evidence that CRC may be a suitable cancer type for anti-GBP5 therapy. Frontiers Media S.A. 2022-09-30 /pmc/articles/PMC9561824/ /pubmed/36246628 http://dx.doi.org/10.3389/fgene.2022.984615 Text en Copyright © 2022 Li, Song, Su, He, Cao, Yang, Li, Huang, Li, Wang, Zhang, Pang and Zheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Li, Xiang Song, Dan Su, Song He, Xiaobo Cao, Fengyu Yang, Chao Li, Kai Huang, Shuoyang Li, Changhua Wang, Chenhong Zhang, Aikang Pang, Pengcheng Zheng, Yongbin Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response |
title | Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response |
title_full | Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response |
title_fullStr | Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response |
title_full_unstemmed | Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response |
title_short | Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response |
title_sort | critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561824/ https://www.ncbi.nlm.nih.gov/pubmed/36246628 http://dx.doi.org/10.3389/fgene.2022.984615 |
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