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ER, Mitochondria, and ISR Regulation by mt‐HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts

Cellular response to protein misfolding underlies multiple diseases. Collagens are the most abundant vertebrate proteins, yet little is known about cellular response to misfolding of their procollagen precursors. Osteoblasts (OBs)—the cells that make bone—produce so much procollagen that it accounts...

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Detalles Bibliográficos
Autores principales: Gorrell, Laura, Makareeva, Elena, Omari, Shakib, Otsuru, Satoru, Leikin, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561870/
https://www.ncbi.nlm.nih.gov/pubmed/35988140
http://dx.doi.org/10.1002/advs.202201273