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NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles

Circulating cell-free mitochondrial DNA (cf-mtDNA) has been found in the plasma of severely ill COVID-19 patients and is now known as a strong predictor of mortality. However, the underlying mechanism of mtDNA release is unexplored. Here, we show a novel mechanism of SARS-CoV-2-mediated pro-inflamma...

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Detalles Bibliográficos
Autores principales:	Faizan, Md Imam, Chaudhuri, Rituparna, Sagar, Shakti, Albogami, Sarah, Chaudhary, Nisha, Azmi, Iqbal, Akhtar, Areej, Ali, Syed Mansoor, Kumar, Rohit, Iqbal, Jawed, Joshi, Mohan C., Kharya, Gaurav, Seth, Pankaj, Roy, Soumya Sinha, Ahmad, Tanveer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561960/ https://www.ncbi.nlm.nih.gov/pubmed/36230930 http://dx.doi.org/10.3390/cells11192969

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