Cargando…
The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease
Endothelial cells comprise the intimal layer of the vasculature, playing a crucial role in facilitating and regulating aspects such nutrient transport, vascular homeostasis, and inflammatory response. Given the importance of these cells in maintaining a healthy haemodynamic environment, dysfunction...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561968/ https://www.ncbi.nlm.nih.gov/pubmed/36231026 http://dx.doi.org/10.3390/cells11193066 |
_version_ | 1784808065421279232 |
---|---|
author | Ladak, Shameem S. McQueen, Liam W. Layton, Georgia R. Aujla, Hardeep Adebayo, Adewale Zakkar, Mustafa |
author_facet | Ladak, Shameem S. McQueen, Liam W. Layton, Georgia R. Aujla, Hardeep Adebayo, Adewale Zakkar, Mustafa |
author_sort | Ladak, Shameem S. |
collection | PubMed |
description | Endothelial cells comprise the intimal layer of the vasculature, playing a crucial role in facilitating and regulating aspects such nutrient transport, vascular homeostasis, and inflammatory response. Given the importance of these cells in maintaining a healthy haemodynamic environment, dysfunction of the endothelium is central to a host of vascular diseases and is a key predictor of cardiovascular risk. Of note, endothelial dysfunction is believed to be a key driver for vein graft disease—a pathology in which vein grafts utilised in coronary artery bypass graft surgery develop intimal hyperplasia and accelerated atherosclerosis, resulting in poor long-term patency rates. Activation and denudation of the endothelium following surgical trauma and implantation of the graft encourage a host of immune, inflammatory, and cellular differentiation responses that risk driving the graft to failure. This review aims to provide an overview of the current working knowledge regarding the role of endothelial cells in the onset, development, and modulation of vein graft disease, as well as addressing current surgical and medical management approaches which aim to beneficially modulate endothelial function and improve patient outcomes. |
format | Online Article Text |
id | pubmed-9561968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95619682022-10-15 The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease Ladak, Shameem S. McQueen, Liam W. Layton, Georgia R. Aujla, Hardeep Adebayo, Adewale Zakkar, Mustafa Cells Review Endothelial cells comprise the intimal layer of the vasculature, playing a crucial role in facilitating and regulating aspects such nutrient transport, vascular homeostasis, and inflammatory response. Given the importance of these cells in maintaining a healthy haemodynamic environment, dysfunction of the endothelium is central to a host of vascular diseases and is a key predictor of cardiovascular risk. Of note, endothelial dysfunction is believed to be a key driver for vein graft disease—a pathology in which vein grafts utilised in coronary artery bypass graft surgery develop intimal hyperplasia and accelerated atherosclerosis, resulting in poor long-term patency rates. Activation and denudation of the endothelium following surgical trauma and implantation of the graft encourage a host of immune, inflammatory, and cellular differentiation responses that risk driving the graft to failure. This review aims to provide an overview of the current working knowledge regarding the role of endothelial cells in the onset, development, and modulation of vein graft disease, as well as addressing current surgical and medical management approaches which aim to beneficially modulate endothelial function and improve patient outcomes. MDPI 2022-09-29 /pmc/articles/PMC9561968/ /pubmed/36231026 http://dx.doi.org/10.3390/cells11193066 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ladak, Shameem S. McQueen, Liam W. Layton, Georgia R. Aujla, Hardeep Adebayo, Adewale Zakkar, Mustafa The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease |
title | The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease |
title_full | The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease |
title_fullStr | The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease |
title_full_unstemmed | The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease |
title_short | The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease |
title_sort | role of endothelial cells in the onset, development and modulation of vein graft disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561968/ https://www.ncbi.nlm.nih.gov/pubmed/36231026 http://dx.doi.org/10.3390/cells11193066 |
work_keys_str_mv | AT ladakshameems theroleofendothelialcellsintheonsetdevelopmentandmodulationofveingraftdisease AT mcqueenliamw theroleofendothelialcellsintheonsetdevelopmentandmodulationofveingraftdisease AT laytongeorgiar theroleofendothelialcellsintheonsetdevelopmentandmodulationofveingraftdisease AT aujlahardeep theroleofendothelialcellsintheonsetdevelopmentandmodulationofveingraftdisease AT adebayoadewale theroleofendothelialcellsintheonsetdevelopmentandmodulationofveingraftdisease AT zakkarmustafa theroleofendothelialcellsintheonsetdevelopmentandmodulationofveingraftdisease AT ladakshameems roleofendothelialcellsintheonsetdevelopmentandmodulationofveingraftdisease AT mcqueenliamw roleofendothelialcellsintheonsetdevelopmentandmodulationofveingraftdisease AT laytongeorgiar roleofendothelialcellsintheonsetdevelopmentandmodulationofveingraftdisease AT aujlahardeep roleofendothelialcellsintheonsetdevelopmentandmodulationofveingraftdisease AT adebayoadewale roleofendothelialcellsintheonsetdevelopmentandmodulationofveingraftdisease AT zakkarmustafa roleofendothelialcellsintheonsetdevelopmentandmodulationofveingraftdisease |