The GBM Tumor Microenvironment as a Modulator of Therapy Response: ADAM8 Causes Tumor Infiltration of Tams through HB-EGF/EGFR-Mediated CCL2 Expression and Overcomes TMZ Chemosensitization in Glioblastoma

SIMPLE SUMMARY: Resistance to standard therapies impose a huge challenge on the treatment for glioblastoma multiforme (GBM), which is often considered as a cell intrinsic property of either GBM or, more significantly, of GBM stem-like cells. Tumor-associated macrophages and microglia (TAMs) take up...

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Detalles Bibliográficos
Autores principales: Liu, Xiaojin, Huang, Yimin, Qi, Yiwei, Wu, Shiqiang, Hu, Feng, Wang, Junwen, Shu, Kai, Zhang, Huaqiu, Bartsch, Jörg W., Nimsky, Christopher, Dong, Fangyong, Lei, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561975/
https://www.ncbi.nlm.nih.gov/pubmed/36230833
http://dx.doi.org/10.3390/cancers14194910

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