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Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases
The calcium-sensing receptor (CaSR), a G-protein-coupled receptor (GPCR), is a cell-surface-located receptor that can induce highly diffusible messengers (IP3, Ca(2+), cAMP) in the cytoplasm to activate various cellular responses. Recently, it has also been suggested that the CaSR mediates the intra...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562006/ https://www.ncbi.nlm.nih.gov/pubmed/36231037 http://dx.doi.org/10.3390/cells11193075 |
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author | Chu, Hezhen Qin, Zhenqian Ma, Jun Xie, Yimin Shi, Haifeng Gu, Jie Shi, Baiqiang |
author_facet | Chu, Hezhen Qin, Zhenqian Ma, Jun Xie, Yimin Shi, Haifeng Gu, Jie Shi, Baiqiang |
author_sort | Chu, Hezhen |
collection | PubMed |
description | The calcium-sensing receptor (CaSR), a G-protein-coupled receptor (GPCR), is a cell-surface-located receptor that can induce highly diffusible messengers (IP3, Ca(2+), cAMP) in the cytoplasm to activate various cellular responses. Recently, it has also been suggested that the CaSR mediates the intracellular communications between the endoplasmic reticulum (ER), mitochondria, nucleus, protease/proteasome, and autophagy–lysosome, which are involved in related cardiovascular diseases. The complex intracellular signaling of this receptor challenges it as a valuable therapeutic target. It is, therefore, necessary to understand the mechanisms behind the signaling characteristics of this receptor in intracellular communication. This review provides an overview of the recent research progress on the various regulatory mechanisms of the CaSR in related cardiovascular diseases and the heart–kidney interaction; the associated common causes are also discussed. |
format | Online Article Text |
id | pubmed-9562006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95620062022-10-15 Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases Chu, Hezhen Qin, Zhenqian Ma, Jun Xie, Yimin Shi, Haifeng Gu, Jie Shi, Baiqiang Cells Review The calcium-sensing receptor (CaSR), a G-protein-coupled receptor (GPCR), is a cell-surface-located receptor that can induce highly diffusible messengers (IP3, Ca(2+), cAMP) in the cytoplasm to activate various cellular responses. Recently, it has also been suggested that the CaSR mediates the intracellular communications between the endoplasmic reticulum (ER), mitochondria, nucleus, protease/proteasome, and autophagy–lysosome, which are involved in related cardiovascular diseases. The complex intracellular signaling of this receptor challenges it as a valuable therapeutic target. It is, therefore, necessary to understand the mechanisms behind the signaling characteristics of this receptor in intracellular communication. This review provides an overview of the recent research progress on the various regulatory mechanisms of the CaSR in related cardiovascular diseases and the heart–kidney interaction; the associated common causes are also discussed. MDPI 2022-09-30 /pmc/articles/PMC9562006/ /pubmed/36231037 http://dx.doi.org/10.3390/cells11193075 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chu, Hezhen Qin, Zhenqian Ma, Jun Xie, Yimin Shi, Haifeng Gu, Jie Shi, Baiqiang Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases |
title | Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases |
title_full | Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases |
title_fullStr | Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases |
title_full_unstemmed | Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases |
title_short | Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases |
title_sort | calcium-sensing receptor (casr)-mediated intracellular communication in cardiovascular diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562006/ https://www.ncbi.nlm.nih.gov/pubmed/36231037 http://dx.doi.org/10.3390/cells11193075 |
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