Cargando…

The Role of the Hypoxia-Related Unfolded Protein Response (UPR) in the Tumor Microenvironment

SIMPLE SUMMARY: The complex signaling networks that different cancers utilize for cell survival remain poorly understood. A major problem is the complexity of the tumor microenvironments (TME). Here, we discuss the role of intermittent hypoxia as one of the inducers of the UPR in the TME and the rel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bartoszewska, Sylwia, Collawn, James F., Bartoszewski, Rafal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562011/ https://www.ncbi.nlm.nih.gov/pubmed/36230792 http://dx.doi.org/10.3390/cancers14194870

Ejemplares similares

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia
por: Bartoszewska, Sylwia, et al.
Publicado: (2020)

Regulation of the unfolded protein response by microRNAs
por: Bartoszewska, Sylwia, et al.
Publicado: (2013)

PIWI proteins contribute to apoptosis during the UPR in human airway epithelial cells
por: Gebert, Magdalena, et al.
Publicado: (2018)

Hypoxia-inducible factor (HIF)-3a2 serves as an endothelial cell fate executor during chronic hypoxia
por: Jaskiewicz, Maciej, et al.
Publicado: (2022)

miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target
por: Serocki, Marcin, et al.
Publicado: (2018)

HIF-1-Induced hsa-miR-429: Understanding Its Direct Targets as the Key to Developing Cancer Diagnostics and Therapies
por: Bartoszewska, Sylwia, et al.
Publicado: (2023)

Posttranscriptional and transcriptional regulation of endothelial nitric-oxide synthase during hypoxia: the role of microRNAs
por: Kalinowski, Leszek, et al.
Publicado: (2016)

The Unfolded Protein Response: A Double-Edged Sword for Brain Health
por: Gebert, Magdalena, et al.
Publicado: (2023)

miR-200b downregulates CFTR during hypoxia in human lung epithelial cells
por: Bartoszewska, Sylwia, et al.
Publicado: (2017)

IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A
por: Gebert, Magdalena, et al.
Publicado: (2023)

eNOS expression and NO release during hypoxia is inhibited by miR-200b in human endothelial cells
por: Janaszak-Jasiecka, Anna, et al.
Publicado: (2018)

miR-429 regulates the transition between Hypoxia-Inducible Factor (HIF)1A and HIF3A expression in human endothelial cells
por: Janaszak-Jasiecka, Anna, et al.
Publicado: (2016)

The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
por: Jaśkiewicz, Maciej, et al.
Publicado: (2022)

Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor
por: Bartoszewska, Sylwia, et al.
Publicado: (2021)

Regulation of angiogenesis by hypoxia: the role of microRNA
por: Madanecki, Piotr, et al.
Publicado: (2012)

Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor
por: Gebert, Magdalena, et al.
Publicado: (2021)

A Role for the Unfolded Protein Response (UPR) in Virulence and Antifungal Susceptibility in Aspergillus fumigatus
por: Richie, Daryl L., et al.
Publicado: (2009)

mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPR(mt))
por: Kenny, Timothy C., et al.
Publicado: (2017)

The mitochondrial unfolded protein response (UPR(mt)) protects against osteoarthritis
por: Zhou, Zhibin, et al.
Publicado: (2022)

Evolutionarily Conserved and Divergent Roles of Unfolded Protein Response (UPR) in the Pathogenic Cryptococcus Species Complex
por: Jung, Kwang-Woo, et al.
Publicado: (2018)

Editorial: Unfolded protein response (UPR): An impending target for multiple neurological disorders
por: Jan, Arif Tasleem, et al.
Publicado: (2022)

SNPs in microRNA target sites and their potential role in human disease
por: Moszyńska, Adrianna, et al.
Publicado: (2017)

PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)
por: Kranz, Philip, et al.
Publicado: (2017)

Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells
por: Hsu, Sheng-Kai, et al.
Publicado: (2019)

Contribution of the Unfolded Protein Response (UPR) to the Pathogenesis of Proteasome-Associated Autoinflammatory Syndromes (PRAAS)
por: Ebstein, Frédéric, et al.
Publicado: (2019)

Diclofenac Diminished the Unfolded Protein Response (UPR) Induced by Tunicamycin in Human Endothelial Cells
por: Sokołowska, Paulina, et al.
Publicado: (2022)

The mitochondrial unfolded protein response (UPR(mt)): shielding against toxicity to mitochondria in cancer
por: Inigo, Joseph R., et al.
Publicado: (2022)

Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR)
por: Botrus, Gehan, et al.
Publicado: (2022)

IRE1 Endoribonuclease Activity Modulates Hypoxic HIF-1α Signaling in Human Endothelial Cells
por: Moszyńska, Adrianna, et al.
Publicado: (2020)

Ubiquitin-Dependent and Independent Proteasomal Degradation in Host-Pathogen Interactions
por: Bialek, Wojciech, et al.
Publicado: (2023)

Discovery of Genes Activated by the Mitochondrial Unfolded Protein Response (mtUPR) and Cognate Promoter Elements
por: Aldridge, Jonathan E., et al.
Publicado: (2007)

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA
por: Herold, M J, et al.
Publicado: (2014)

Immunogenic landscape and risk score prediction based on unfolded protein response (UPR)-related molecular subtypes in hepatocellular carcinoma
por: Guo, Hanyao, et al.
Publicado: (2023)

Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells
por: Sauzay, Chloé, et al.
Publicado: (2018)

Interplay between Redox Signaling, Oxidative Stress, and Unfolded Protein Response (UPR) in Pathogenesis of Human Diseases
por: Poplawski, Tomasz, et al.
Publicado: (2019)

Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator
por: Bartoszewski, Rafal, et al.
Publicado: (2016)

Dissecting Endoplasmic Reticulum Unfolded Protein Response (UPR(ER)) in Managing Clandestine Modus Operandi of Alzheimer’s Disease
por: Rahman, Safikur, et al.
Publicado: (2018)

Endoplasmic Reticulum (ER) Stress and Unfolded Protein Response (UPR) in Mammalian Oocyte Maturation and Preimplantation Embryo Development
por: Lin, Tao, et al.
Publicado: (2019)

Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible changes
por: Wärri, Anni, et al.
Publicado: (2018)

Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR)
por: Guirao-Abad, José P., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_no8jr8iiu5q6t6p7v963afltd4