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Comparative Study of Hypo-Fractionated Radiotherapy Versus Conventional Radiotherapy in Breast Cancer

Background: Breast cancer is the most commonly diagnosed cancer causing death among females worldwide. Radiotherapy after lumpectomy/mastectomy in breast cancer cases is a successful treatment modality taking five weeks to complete. The aim of the present study is to compare the effectiveness of hyp...

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Autores principales: Narwariya, Abhinav, Dhakar, Mhendr, Jatav, Jagannath, Prajapati, Raju, Bayer, Sujata, Moosa, Shajiya sarwar, Shaikh, Mohammad habeebur raheman, Ali, Mohammed Taher, Ahmad, Arafat, Begum, Yousuf, Hiware, Sanket D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562256/
https://www.ncbi.nlm.nih.gov/pubmed/36259037
http://dx.doi.org/10.7759/cureus.29147
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author Narwariya, Abhinav
Dhakar, Mhendr
Jatav, Jagannath
Prajapati, Raju
Bayer, Sujata
Moosa, Shajiya sarwar
Shaikh, Mohammad habeebur raheman
Ali, Mohammed Taher
Ahmad, Arafat
Begum, Yousuf
Hiware, Sanket D
author_facet Narwariya, Abhinav
Dhakar, Mhendr
Jatav, Jagannath
Prajapati, Raju
Bayer, Sujata
Moosa, Shajiya sarwar
Shaikh, Mohammad habeebur raheman
Ali, Mohammed Taher
Ahmad, Arafat
Begum, Yousuf
Hiware, Sanket D
author_sort Narwariya, Abhinav
collection PubMed
description Background: Breast cancer is the most commonly diagnosed cancer causing death among females worldwide. Radiotherapy after lumpectomy/mastectomy in breast cancer cases is a successful treatment modality taking five weeks to complete. The aim of the present study is to compare the effectiveness of hypo-fractionated radiotherapy in breast cancer patients with conventional radiotherapy with respect to outcome and toxicity. Methods: Sixty patients were randomly divided equally into a conventional group, Group A (dose: 50 Gy in 25 fractions), and a hypo-fractionated short-course radiotherapy group, Group B (dose: 40 Gy in 16 fractions). After thorough clinical and laboratory examination of all patients, the disease status was assessed prior to radiotherapy and three and six months after completion of radiotherapy. The cardiopulmonary function was assessed using echocardiography and pulmonary function tests prior to the procedure. The assessment of the development of toxicity (dysphagia, skin, lung, and lymphedema) was done during every clinical visit. Results: The mean age of patients was 53.28 ± 9.73 years in Group A, and 55.67 ± 10.41 years in Group B (p=0.82). The right breast was involved in 13 (43.4%) patients in Group A and 14 (46.6%) in Group B, and the left breast was involved n 17 (56.6%) patients in Group A and 16 (53.4%) in Group B (p=0.81). Most of the patients were post-menopausal; 24 (80%) in Group A and 25 (83.4%) in Group B (p=0.91). Eleven (36.6%) patients were of stage T2N1M0 in both groups. However, no statistical difference was observed between the groups in the TNM (tumor, node, and metastasis) staging using the AJCC (American Joint Committee on Cancer) criteria (p=0.26). On comparing the responses in Group A and Group B, no significant difference was observed in either of the groups from immediate post-treatment to the 12-month follow-up period (p=0.53 and p=0.64, respectively). Conclusion: Hypo-fractionated radiotherapy is as effective as conventional radiotherapy and can be used as an alternative method for treatment following breast cancer surgery.
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spelling pubmed-95622562022-10-17 Comparative Study of Hypo-Fractionated Radiotherapy Versus Conventional Radiotherapy in Breast Cancer Narwariya, Abhinav Dhakar, Mhendr Jatav, Jagannath Prajapati, Raju Bayer, Sujata Moosa, Shajiya sarwar Shaikh, Mohammad habeebur raheman Ali, Mohammed Taher Ahmad, Arafat Begum, Yousuf Hiware, Sanket D Cureus Radiation Oncology Background: Breast cancer is the most commonly diagnosed cancer causing death among females worldwide. Radiotherapy after lumpectomy/mastectomy in breast cancer cases is a successful treatment modality taking five weeks to complete. The aim of the present study is to compare the effectiveness of hypo-fractionated radiotherapy in breast cancer patients with conventional radiotherapy with respect to outcome and toxicity. Methods: Sixty patients were randomly divided equally into a conventional group, Group A (dose: 50 Gy in 25 fractions), and a hypo-fractionated short-course radiotherapy group, Group B (dose: 40 Gy in 16 fractions). After thorough clinical and laboratory examination of all patients, the disease status was assessed prior to radiotherapy and three and six months after completion of radiotherapy. The cardiopulmonary function was assessed using echocardiography and pulmonary function tests prior to the procedure. The assessment of the development of toxicity (dysphagia, skin, lung, and lymphedema) was done during every clinical visit. Results: The mean age of patients was 53.28 ± 9.73 years in Group A, and 55.67 ± 10.41 years in Group B (p=0.82). The right breast was involved in 13 (43.4%) patients in Group A and 14 (46.6%) in Group B, and the left breast was involved n 17 (56.6%) patients in Group A and 16 (53.4%) in Group B (p=0.81). Most of the patients were post-menopausal; 24 (80%) in Group A and 25 (83.4%) in Group B (p=0.91). Eleven (36.6%) patients were of stage T2N1M0 in both groups. However, no statistical difference was observed between the groups in the TNM (tumor, node, and metastasis) staging using the AJCC (American Joint Committee on Cancer) criteria (p=0.26). On comparing the responses in Group A and Group B, no significant difference was observed in either of the groups from immediate post-treatment to the 12-month follow-up period (p=0.53 and p=0.64, respectively). Conclusion: Hypo-fractionated radiotherapy is as effective as conventional radiotherapy and can be used as an alternative method for treatment following breast cancer surgery. Cureus 2022-09-14 /pmc/articles/PMC9562256/ /pubmed/36259037 http://dx.doi.org/10.7759/cureus.29147 Text en Copyright © 2022, Narwariya et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Radiation Oncology
Narwariya, Abhinav
Dhakar, Mhendr
Jatav, Jagannath
Prajapati, Raju
Bayer, Sujata
Moosa, Shajiya sarwar
Shaikh, Mohammad habeebur raheman
Ali, Mohammed Taher
Ahmad, Arafat
Begum, Yousuf
Hiware, Sanket D
Comparative Study of Hypo-Fractionated Radiotherapy Versus Conventional Radiotherapy in Breast Cancer
title Comparative Study of Hypo-Fractionated Radiotherapy Versus Conventional Radiotherapy in Breast Cancer
title_full Comparative Study of Hypo-Fractionated Radiotherapy Versus Conventional Radiotherapy in Breast Cancer
title_fullStr Comparative Study of Hypo-Fractionated Radiotherapy Versus Conventional Radiotherapy in Breast Cancer
title_full_unstemmed Comparative Study of Hypo-Fractionated Radiotherapy Versus Conventional Radiotherapy in Breast Cancer
title_short Comparative Study of Hypo-Fractionated Radiotherapy Versus Conventional Radiotherapy in Breast Cancer
title_sort comparative study of hypo-fractionated radiotherapy versus conventional radiotherapy in breast cancer
topic Radiation Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562256/
https://www.ncbi.nlm.nih.gov/pubmed/36259037
http://dx.doi.org/10.7759/cureus.29147
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