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Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons

The use of human derived induced pluripotent stem cells (hiPSCs) differentiated to dopaminergic (DA) neurons offers a valuable experimental model to decorticate the cellular and molecular mechanisms of Parkinson’s disease (PD) pathogenesis. However, the existing approaches present with several limit...

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Detalles Bibliográficos
Autores principales:	Sheta, Razan, Teixeira, Maxime, Idi, Walid, Pierre, Marion, de Rus Jacquet, Aurelie, Emond, Vincent, Zorca, Cornelia E., Vanderperre, Benoît, Durcan, Thomas M., Fon, Edward A., Calon, Frédéric, Chahine, Mohamed, Oueslati, Abid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562300/ https://www.ncbi.nlm.nih.gov/pubmed/36229560 http://dx.doi.org/10.1038/s41598-022-22158-4

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