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Thyroid storm induced by combined nivolumab and ipilimumab immunotherapy in advanced non-small cell lung cancer

Thyroid storm is a rare and life-threatening condition associated with excess thyroid hormones. Early detection of thyroid storm is the key to decreasing the morbidity and mortality associated with this condition. We present a rare case of thyroid storm induced by combination therapy with nivolumab...

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Autores principales: Kataoka, Shunichi, Matsuno, Kei, Sugano, Koji, Takahashi, Kazuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562321/
https://www.ncbi.nlm.nih.gov/pubmed/36223974
http://dx.doi.org/10.1136/bcr-2022-250696
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author Kataoka, Shunichi
Matsuno, Kei
Sugano, Koji
Takahashi, Kazuhisa
author_facet Kataoka, Shunichi
Matsuno, Kei
Sugano, Koji
Takahashi, Kazuhisa
author_sort Kataoka, Shunichi
collection PubMed
description Thyroid storm is a rare and life-threatening condition associated with excess thyroid hormones. Early detection of thyroid storm is the key to decreasing the morbidity and mortality associated with this condition. We present a rare case of thyroid storm induced by combination therapy with nivolumab and ipilimumab in a patient with advanced non-small cell lung cancer (NSCLC). Because of prominent hyperthyroidism with gastrointestinal symptoms and signs of heart failure, the patient was diagnosed with thyroid storm 3 weeks after initiating this combination immunotherapy. The patient had no history of thyroid disease but was positive for antithyroid antibodies. This case report suggests that thyroid function and symptoms of suspected thyroid storm should be evaluated routinely within 3 weeks from the initiation of therapy when combination therapy is administered in patients with NSCLC positive for antithyroid antibodies.
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spelling pubmed-95623212022-10-15 Thyroid storm induced by combined nivolumab and ipilimumab immunotherapy in advanced non-small cell lung cancer Kataoka, Shunichi Matsuno, Kei Sugano, Koji Takahashi, Kazuhisa BMJ Case Rep Case Reports: Adverse drug reactions and complications Thyroid storm is a rare and life-threatening condition associated with excess thyroid hormones. Early detection of thyroid storm is the key to decreasing the morbidity and mortality associated with this condition. We present a rare case of thyroid storm induced by combination therapy with nivolumab and ipilimumab in a patient with advanced non-small cell lung cancer (NSCLC). Because of prominent hyperthyroidism with gastrointestinal symptoms and signs of heart failure, the patient was diagnosed with thyroid storm 3 weeks after initiating this combination immunotherapy. The patient had no history of thyroid disease but was positive for antithyroid antibodies. This case report suggests that thyroid function and symptoms of suspected thyroid storm should be evaluated routinely within 3 weeks from the initiation of therapy when combination therapy is administered in patients with NSCLC positive for antithyroid antibodies. BMJ Publishing Group 2022-10-12 /pmc/articles/PMC9562321/ /pubmed/36223974 http://dx.doi.org/10.1136/bcr-2022-250696 Text en © BMJ Publishing Group Limited 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Reports: Adverse drug reactions and complications
Kataoka, Shunichi
Matsuno, Kei
Sugano, Koji
Takahashi, Kazuhisa
Thyroid storm induced by combined nivolumab and ipilimumab immunotherapy in advanced non-small cell lung cancer
title Thyroid storm induced by combined nivolumab and ipilimumab immunotherapy in advanced non-small cell lung cancer
title_full Thyroid storm induced by combined nivolumab and ipilimumab immunotherapy in advanced non-small cell lung cancer
title_fullStr Thyroid storm induced by combined nivolumab and ipilimumab immunotherapy in advanced non-small cell lung cancer
title_full_unstemmed Thyroid storm induced by combined nivolumab and ipilimumab immunotherapy in advanced non-small cell lung cancer
title_short Thyroid storm induced by combined nivolumab and ipilimumab immunotherapy in advanced non-small cell lung cancer
title_sort thyroid storm induced by combined nivolumab and ipilimumab immunotherapy in advanced non-small cell lung cancer
topic Case Reports: Adverse drug reactions and complications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562321/
https://www.ncbi.nlm.nih.gov/pubmed/36223974
http://dx.doi.org/10.1136/bcr-2022-250696
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