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Relevance of sex-differenced analyses in bioenergetics and nutritional studies
Sex-biased analyses still remain as one of the biggest limitations to obtain universal conclusions. In biomedicine, the majority of experimental analyses and a significant amount of patient-derived cohort studies exclusively included males. In nutritional and molecular medicine, sex-influence is als...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562369/ https://www.ncbi.nlm.nih.gov/pubmed/36245509 http://dx.doi.org/10.3389/fnut.2022.936929 |
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author | Garrabou, Glòria García-García, Francesc Josep Presmanes, Rosa Elvira Feu, Maria Chiva-Blanch, Gemma |
author_facet | Garrabou, Glòria García-García, Francesc Josep Presmanes, Rosa Elvira Feu, Maria Chiva-Blanch, Gemma |
author_sort | Garrabou, Glòria |
collection | PubMed |
description | Sex-biased analyses still remain as one of the biggest limitations to obtain universal conclusions. In biomedicine, the majority of experimental analyses and a significant amount of patient-derived cohort studies exclusively included males. In nutritional and molecular medicine, sex-influence is also frequently underrated, even considering maternal-inherited organelles such as mitochondria. We herein illustrate with in-house original data examples of how sex influences mitochondrial homeostasis, review these topics and highlight the consequences of biasing scientific analyses excluding females as differentiated entities from males. |
format | Online Article Text |
id | pubmed-9562369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95623692022-10-15 Relevance of sex-differenced analyses in bioenergetics and nutritional studies Garrabou, Glòria García-García, Francesc Josep Presmanes, Rosa Elvira Feu, Maria Chiva-Blanch, Gemma Front Nutr Nutrition Sex-biased analyses still remain as one of the biggest limitations to obtain universal conclusions. In biomedicine, the majority of experimental analyses and a significant amount of patient-derived cohort studies exclusively included males. In nutritional and molecular medicine, sex-influence is also frequently underrated, even considering maternal-inherited organelles such as mitochondria. We herein illustrate with in-house original data examples of how sex influences mitochondrial homeostasis, review these topics and highlight the consequences of biasing scientific analyses excluding females as differentiated entities from males. Frontiers Media S.A. 2022-09-30 /pmc/articles/PMC9562369/ /pubmed/36245509 http://dx.doi.org/10.3389/fnut.2022.936929 Text en Copyright © 2022 Garrabou, García-García, Presmanes, Feu and Chiva-Blanch. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Garrabou, Glòria García-García, Francesc Josep Presmanes, Rosa Elvira Feu, Maria Chiva-Blanch, Gemma Relevance of sex-differenced analyses in bioenergetics and nutritional studies |
title | Relevance of sex-differenced analyses in bioenergetics and nutritional studies |
title_full | Relevance of sex-differenced analyses in bioenergetics and nutritional studies |
title_fullStr | Relevance of sex-differenced analyses in bioenergetics and nutritional studies |
title_full_unstemmed | Relevance of sex-differenced analyses in bioenergetics and nutritional studies |
title_short | Relevance of sex-differenced analyses in bioenergetics and nutritional studies |
title_sort | relevance of sex-differenced analyses in bioenergetics and nutritional studies |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562369/ https://www.ncbi.nlm.nih.gov/pubmed/36245509 http://dx.doi.org/10.3389/fnut.2022.936929 |
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