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Relevance of sex-differenced analyses in bioenergetics and nutritional studies

Sex-biased analyses still remain as one of the biggest limitations to obtain universal conclusions. In biomedicine, the majority of experimental analyses and a significant amount of patient-derived cohort studies exclusively included males. In nutritional and molecular medicine, sex-influence is als...

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Autores principales: Garrabou, Glòria, García-García, Francesc Josep, Presmanes, Rosa Elvira, Feu, Maria, Chiva-Blanch, Gemma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562369/
https://www.ncbi.nlm.nih.gov/pubmed/36245509
http://dx.doi.org/10.3389/fnut.2022.936929
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author Garrabou, Glòria
García-García, Francesc Josep
Presmanes, Rosa Elvira
Feu, Maria
Chiva-Blanch, Gemma
author_facet Garrabou, Glòria
García-García, Francesc Josep
Presmanes, Rosa Elvira
Feu, Maria
Chiva-Blanch, Gemma
author_sort Garrabou, Glòria
collection PubMed
description Sex-biased analyses still remain as one of the biggest limitations to obtain universal conclusions. In biomedicine, the majority of experimental analyses and a significant amount of patient-derived cohort studies exclusively included males. In nutritional and molecular medicine, sex-influence is also frequently underrated, even considering maternal-inherited organelles such as mitochondria. We herein illustrate with in-house original data examples of how sex influences mitochondrial homeostasis, review these topics and highlight the consequences of biasing scientific analyses excluding females as differentiated entities from males.
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spelling pubmed-95623692022-10-15 Relevance of sex-differenced analyses in bioenergetics and nutritional studies Garrabou, Glòria García-García, Francesc Josep Presmanes, Rosa Elvira Feu, Maria Chiva-Blanch, Gemma Front Nutr Nutrition Sex-biased analyses still remain as one of the biggest limitations to obtain universal conclusions. In biomedicine, the majority of experimental analyses and a significant amount of patient-derived cohort studies exclusively included males. In nutritional and molecular medicine, sex-influence is also frequently underrated, even considering maternal-inherited organelles such as mitochondria. We herein illustrate with in-house original data examples of how sex influences mitochondrial homeostasis, review these topics and highlight the consequences of biasing scientific analyses excluding females as differentiated entities from males. Frontiers Media S.A. 2022-09-30 /pmc/articles/PMC9562369/ /pubmed/36245509 http://dx.doi.org/10.3389/fnut.2022.936929 Text en Copyright © 2022 Garrabou, García-García, Presmanes, Feu and Chiva-Blanch. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Garrabou, Glòria
García-García, Francesc Josep
Presmanes, Rosa Elvira
Feu, Maria
Chiva-Blanch, Gemma
Relevance of sex-differenced analyses in bioenergetics and nutritional studies
title Relevance of sex-differenced analyses in bioenergetics and nutritional studies
title_full Relevance of sex-differenced analyses in bioenergetics and nutritional studies
title_fullStr Relevance of sex-differenced analyses in bioenergetics and nutritional studies
title_full_unstemmed Relevance of sex-differenced analyses in bioenergetics and nutritional studies
title_short Relevance of sex-differenced analyses in bioenergetics and nutritional studies
title_sort relevance of sex-differenced analyses in bioenergetics and nutritional studies
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562369/
https://www.ncbi.nlm.nih.gov/pubmed/36245509
http://dx.doi.org/10.3389/fnut.2022.936929
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