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Amyloid fibrillation of the glaucoma associated myocilin protein is inhibited by epicatechin gallate (ECG)
Inherited glaucoma is a recent addition to the inventory of diseases arising due to protein misfolding. Mutations in the olfactomedin (OLF) domain of myocilin are the most common genetic cause behind this disease. Disease associated variants of m-OLF are predisposed to misfold and aggregate in the t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562371/ https://www.ncbi.nlm.nih.gov/pubmed/36320765 http://dx.doi.org/10.1039/d2ra05061g |