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Utility of Biochemical Markers in Predicting Severe COVID-19: Experience from a Tertiary Hospital in South India
BACKGROUND: Coronavirus Disease 2019 (COVID-19) patients can present with a wide array of symptoms. For laboratory investigation of these patients several biochemical tests are routinely requested. Here we wanted to evaluate the utility of procalcitonin (PCT), ferritin, D-dimer, interleukin 6 (IL-6)...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Communications and Publications Division (CPD) of the IFCC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562479/ https://www.ncbi.nlm.nih.gov/pubmed/36313911 |
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author | Shenoy, Mamatha T. Mohanty, Pradipta Kumar Suganthy, K. Manavalan, Jeya Kumar Alexander, Hariharan |
author_facet | Shenoy, Mamatha T. Mohanty, Pradipta Kumar Suganthy, K. Manavalan, Jeya Kumar Alexander, Hariharan |
author_sort | Shenoy, Mamatha T. |
collection | PubMed |
description | BACKGROUND: Coronavirus Disease 2019 (COVID-19) patients can present with a wide array of symptoms. For laboratory investigation of these patients several biochemical tests are routinely requested. Here we wanted to evaluate the utility of procalcitonin (PCT), ferritin, D-dimer, interleukin 6 (IL-6) and total lactate dehydrogenase (LDH) activity in predicting severe COVID-19 infection. PATIENTS AND METHODS: This study was undertaken at a tertiary care medical hospital in Tamil Nadu, India representing 183 COVID-19 RT-PCR positive patients, who were grouped based on their disease severity as mild (n=21), moderate (n=115) and severe (n=47) cohorts. All routine clinical chemistry analysis was performed as part of routine baseline assessment. Biomarkers of inflammation and infection were tested via the measurement of IL-6, PCT, ferritin, and D-dimer. Serum IL-6 concentration was estimated by ELISA, while total LDH activity was analyzed by kinetic colorimetric assay. Serum ferritin, PCT and D-dimer were measured by fluorescent immunoassay by sandwich immuno-detection method. RESULTS: Biomarkers were significantly different among subgroups, and the highest concentrations were found in those with intensive care unit (ICU) admission. Serum PCT showed the best power to predict the need for ICU treatment followed by D-dimer, IL-6 and total LDH. Based on the AUC-ROC analysis, mortality was most effectively indicated by D-dimer followed by PCT, LDH, IL-6 and ferritin. CONCLUSION: Our study highlights the utility of some routinely available biochemical tests in the management of severe COVID-19. The higher baseline values of these biomarkers hint towards the probability of severe infection and a larger risk of death. |
format | Online Article Text |
id | pubmed-9562479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Communications and Publications Division (CPD) of the IFCC |
record_format | MEDLINE/PubMed |
spelling | pubmed-95624792022-10-28 Utility of Biochemical Markers in Predicting Severe COVID-19: Experience from a Tertiary Hospital in South India Shenoy, Mamatha T. Mohanty, Pradipta Kumar Suganthy, K. Manavalan, Jeya Kumar Alexander, Hariharan EJIFCC Research Article BACKGROUND: Coronavirus Disease 2019 (COVID-19) patients can present with a wide array of symptoms. For laboratory investigation of these patients several biochemical tests are routinely requested. Here we wanted to evaluate the utility of procalcitonin (PCT), ferritin, D-dimer, interleukin 6 (IL-6) and total lactate dehydrogenase (LDH) activity in predicting severe COVID-19 infection. PATIENTS AND METHODS: This study was undertaken at a tertiary care medical hospital in Tamil Nadu, India representing 183 COVID-19 RT-PCR positive patients, who were grouped based on their disease severity as mild (n=21), moderate (n=115) and severe (n=47) cohorts. All routine clinical chemistry analysis was performed as part of routine baseline assessment. Biomarkers of inflammation and infection were tested via the measurement of IL-6, PCT, ferritin, and D-dimer. Serum IL-6 concentration was estimated by ELISA, while total LDH activity was analyzed by kinetic colorimetric assay. Serum ferritin, PCT and D-dimer were measured by fluorescent immunoassay by sandwich immuno-detection method. RESULTS: Biomarkers were significantly different among subgroups, and the highest concentrations were found in those with intensive care unit (ICU) admission. Serum PCT showed the best power to predict the need for ICU treatment followed by D-dimer, IL-6 and total LDH. Based on the AUC-ROC analysis, mortality was most effectively indicated by D-dimer followed by PCT, LDH, IL-6 and ferritin. CONCLUSION: Our study highlights the utility of some routinely available biochemical tests in the management of severe COVID-19. The higher baseline values of these biomarkers hint towards the probability of severe infection and a larger risk of death. The Communications and Publications Division (CPD) of the IFCC 2022-08-08 /pmc/articles/PMC9562479/ /pubmed/36313911 Text en Copyright © 2022 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This is a Platinum Open Access Journal distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shenoy, Mamatha T. Mohanty, Pradipta Kumar Suganthy, K. Manavalan, Jeya Kumar Alexander, Hariharan Utility of Biochemical Markers in Predicting Severe COVID-19: Experience from a Tertiary Hospital in South India |
title | Utility of Biochemical Markers in Predicting Severe COVID-19: Experience from a Tertiary Hospital in South India |
title_full | Utility of Biochemical Markers in Predicting Severe COVID-19: Experience from a Tertiary Hospital in South India |
title_fullStr | Utility of Biochemical Markers in Predicting Severe COVID-19: Experience from a Tertiary Hospital in South India |
title_full_unstemmed | Utility of Biochemical Markers in Predicting Severe COVID-19: Experience from a Tertiary Hospital in South India |
title_short | Utility of Biochemical Markers in Predicting Severe COVID-19: Experience from a Tertiary Hospital in South India |
title_sort | utility of biochemical markers in predicting severe covid-19: experience from a tertiary hospital in south india |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562479/ https://www.ncbi.nlm.nih.gov/pubmed/36313911 |
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