Cargando…

Skeletal muscle and related protein expression as prognostic factors in thymic squamous cell carcinoma

BACKGROUND: Sarcopenia and its marker, the psoas muscle index (PMI), have attracted attention as prognostic factors for various types of cancers. The fragile X-related 1 (FXR1) gene is highly expressed in myocytes, and FXR1 overexpression is a candidate biomarker for poor survival in several types o...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakanishi, Keita, Ozeki, Naoki, Tateyama, Hisashi, Kadomatsu, Yuka, Ueno, Harushi, Goto, Masaki, Nakamura, Shota, Fukumoto, Koichi, Chen-Yoshikawa, Toyofumi Fengshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562531/
https://www.ncbi.nlm.nih.gov/pubmed/36245599
http://dx.doi.org/10.21037/jtd-22-385
_version_ 1784808194800877568
author Nakanishi, Keita
Ozeki, Naoki
Tateyama, Hisashi
Kadomatsu, Yuka
Ueno, Harushi
Goto, Masaki
Nakamura, Shota
Fukumoto, Koichi
Chen-Yoshikawa, Toyofumi Fengshi
author_facet Nakanishi, Keita
Ozeki, Naoki
Tateyama, Hisashi
Kadomatsu, Yuka
Ueno, Harushi
Goto, Masaki
Nakamura, Shota
Fukumoto, Koichi
Chen-Yoshikawa, Toyofumi Fengshi
author_sort Nakanishi, Keita
collection PubMed
description BACKGROUND: Sarcopenia and its marker, the psoas muscle index (PMI), have attracted attention as prognostic factors for various types of cancers. The fragile X-related 1 (FXR1) gene is highly expressed in myocytes, and FXR1 overexpression is a candidate biomarker for poor survival in several types of cancers. Thymic squamous cell carcinoma (TSQCC) is rare, and no studies assessing its prognostic factors, particularly in terms of skeletal muscle mass and FXR1 expression, are available. METHODS: We retrospectively investigated the prognostic significance of PMI in 34 patients who underwent TSQCC resection, considering the status of FXR1 and tumor programmed death-ligand 1 (PD-L1). PMI was calculated from the bilateral psoas muscle using preoperative computed tomography (CT). Patients were divided into two groups: low PMI (<58.2%, n=17) and normal PMI (≥58.2%, n=17). Immunohistochemical analysis was performed to determine the FXR1 and PD-L1 expression levels. RESULTS: Low PMI was significantly associated with worse overall survival (OS) (5-year survival rate; 86% vs. 100%; P=0.026) and marginally associated with worse disease-free survival (DFS) (5-year survival rate; 39% vs. 66%; P=0.090) compared with normal PMI. The immunohistochemical analysis revealed that the FXR1 intensity score (0–1+: 6% vs. 0%; 2+–3+: 94% vs. 100%; P=0.31), median FXR1 distribution (95% vs. 90%; P=0.63), and PD-L1 status (high: 47% vs. 59%; P=0.49) were not significantly different between the two groups. CONCLUSIONS: Our findings suggest that PMI might be considered as a potential prognostic factor in TSQCC and that FXR1 is widely expressed regardless of the PMI status. Skeletal muscle mass may play a role in the prognosis of TSQCC.
format Online
Article
Text
id pubmed-9562531
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-95625312022-10-15 Skeletal muscle and related protein expression as prognostic factors in thymic squamous cell carcinoma Nakanishi, Keita Ozeki, Naoki Tateyama, Hisashi Kadomatsu, Yuka Ueno, Harushi Goto, Masaki Nakamura, Shota Fukumoto, Koichi Chen-Yoshikawa, Toyofumi Fengshi J Thorac Dis Original Article BACKGROUND: Sarcopenia and its marker, the psoas muscle index (PMI), have attracted attention as prognostic factors for various types of cancers. The fragile X-related 1 (FXR1) gene is highly expressed in myocytes, and FXR1 overexpression is a candidate biomarker for poor survival in several types of cancers. Thymic squamous cell carcinoma (TSQCC) is rare, and no studies assessing its prognostic factors, particularly in terms of skeletal muscle mass and FXR1 expression, are available. METHODS: We retrospectively investigated the prognostic significance of PMI in 34 patients who underwent TSQCC resection, considering the status of FXR1 and tumor programmed death-ligand 1 (PD-L1). PMI was calculated from the bilateral psoas muscle using preoperative computed tomography (CT). Patients were divided into two groups: low PMI (<58.2%, n=17) and normal PMI (≥58.2%, n=17). Immunohistochemical analysis was performed to determine the FXR1 and PD-L1 expression levels. RESULTS: Low PMI was significantly associated with worse overall survival (OS) (5-year survival rate; 86% vs. 100%; P=0.026) and marginally associated with worse disease-free survival (DFS) (5-year survival rate; 39% vs. 66%; P=0.090) compared with normal PMI. The immunohistochemical analysis revealed that the FXR1 intensity score (0–1+: 6% vs. 0%; 2+–3+: 94% vs. 100%; P=0.31), median FXR1 distribution (95% vs. 90%; P=0.63), and PD-L1 status (high: 47% vs. 59%; P=0.49) were not significantly different between the two groups. CONCLUSIONS: Our findings suggest that PMI might be considered as a potential prognostic factor in TSQCC and that FXR1 is widely expressed regardless of the PMI status. Skeletal muscle mass may play a role in the prognosis of TSQCC. AME Publishing Company 2022-09 /pmc/articles/PMC9562531/ /pubmed/36245599 http://dx.doi.org/10.21037/jtd-22-385 Text en 2022 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Nakanishi, Keita
Ozeki, Naoki
Tateyama, Hisashi
Kadomatsu, Yuka
Ueno, Harushi
Goto, Masaki
Nakamura, Shota
Fukumoto, Koichi
Chen-Yoshikawa, Toyofumi Fengshi
Skeletal muscle and related protein expression as prognostic factors in thymic squamous cell carcinoma
title Skeletal muscle and related protein expression as prognostic factors in thymic squamous cell carcinoma
title_full Skeletal muscle and related protein expression as prognostic factors in thymic squamous cell carcinoma
title_fullStr Skeletal muscle and related protein expression as prognostic factors in thymic squamous cell carcinoma
title_full_unstemmed Skeletal muscle and related protein expression as prognostic factors in thymic squamous cell carcinoma
title_short Skeletal muscle and related protein expression as prognostic factors in thymic squamous cell carcinoma
title_sort skeletal muscle and related protein expression as prognostic factors in thymic squamous cell carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562531/
https://www.ncbi.nlm.nih.gov/pubmed/36245599
http://dx.doi.org/10.21037/jtd-22-385
work_keys_str_mv AT nakanishikeita skeletalmuscleandrelatedproteinexpressionasprognosticfactorsinthymicsquamouscellcarcinoma
AT ozekinaoki skeletalmuscleandrelatedproteinexpressionasprognosticfactorsinthymicsquamouscellcarcinoma
AT tateyamahisashi skeletalmuscleandrelatedproteinexpressionasprognosticfactorsinthymicsquamouscellcarcinoma
AT kadomatsuyuka skeletalmuscleandrelatedproteinexpressionasprognosticfactorsinthymicsquamouscellcarcinoma
AT uenoharushi skeletalmuscleandrelatedproteinexpressionasprognosticfactorsinthymicsquamouscellcarcinoma
AT gotomasaki skeletalmuscleandrelatedproteinexpressionasprognosticfactorsinthymicsquamouscellcarcinoma
AT nakamurashota skeletalmuscleandrelatedproteinexpressionasprognosticfactorsinthymicsquamouscellcarcinoma
AT fukumotokoichi skeletalmuscleandrelatedproteinexpressionasprognosticfactorsinthymicsquamouscellcarcinoma
AT chenyoshikawatoyofumifengshi skeletalmuscleandrelatedproteinexpressionasprognosticfactorsinthymicsquamouscellcarcinoma