Targeting intrinsically disordered regions facilitates discovery of calcium channels 3.2 inhibitory peptides for adeno-associated virus–mediated peripheral analgesia

Ample data support a prominent role of peripheral T-type calcium channels 3.2 (Ca(V)3.2) in generating pain states. Development of primary sensory neuron-specific inhibitors of Ca(V)3.2 channels is an opportunity for achieving effective analgesic therapeutics, but success has been elusive. Small pep...

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Detalles Bibliográficos
Autores principales: Shin, Seung Min, Lauzadis, Justas, Itson-Zoske, Brandon, Cai, Yongsong, Fan, Fan, Natarajan, Gayathri K., Kwok, Wai-Meng, Puopolo, Michelino, Hogan, Quinn H., Yu, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562599/
https://www.ncbi.nlm.nih.gov/pubmed/35420557
http://dx.doi.org/10.1097/j.pain.0000000000002650

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