Vitamin D status can affect COVID-19 outcomes also in pediatric population

BACKGROUND: vitamin D influences the immune system and the inflammatory response. It is known that vitamin D supplementation reduces the risk of acute respiratory tract infection. In the last two years, many researchers have investigated vitamin D’s role in the pathophysiology of COVID-19 disease. R...

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Autores principales: Miraglia del Giudice, Michele, Indolfi, Cristiana, Dinardo, Giulio, Decimo, Fabio, Decimo, Alberto, Klain, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562619/
https://www.ncbi.nlm.nih.gov/pubmed/36268528
http://dx.doi.org/10.1016/j.phanu.2022.100319
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author Miraglia del Giudice, Michele
Indolfi, Cristiana
Dinardo, Giulio
Decimo, Fabio
Decimo, Alberto
Klain, Angela
author_facet Miraglia del Giudice, Michele
Indolfi, Cristiana
Dinardo, Giulio
Decimo, Fabio
Decimo, Alberto
Klain, Angela
author_sort Miraglia del Giudice, Michele
collection PubMed
description BACKGROUND: vitamin D influences the immune system and the inflammatory response. It is known that vitamin D supplementation reduces the risk of acute respiratory tract infection. In the last two years, many researchers have investigated vitamin D’s role in the pathophysiology of COVID-19 disease. RESULTS: the findings obtained from clinical trials and systematic reviews highlight that most patients with COVID-19 have decreased vitamin D levels and low levels of vitamin D increase the risk of severe disease. This evidence seems to be also confirmed in the pediatric population. CONCLUSIONS: further studies (systematic review and meta-analysis) conducted on children are needed to confirm that vitamin D affects COVID-19 outcomes and to determine the effectiveness of supplementation and the appropriate dose, duration and mode of administration.
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spelling pubmed-95626192022-10-16 Vitamin D status can affect COVID-19 outcomes also in pediatric population Miraglia del Giudice, Michele Indolfi, Cristiana Dinardo, Giulio Decimo, Fabio Decimo, Alberto Klain, Angela PharmaNutrition Article BACKGROUND: vitamin D influences the immune system and the inflammatory response. It is known that vitamin D supplementation reduces the risk of acute respiratory tract infection. In the last two years, many researchers have investigated vitamin D’s role in the pathophysiology of COVID-19 disease. RESULTS: the findings obtained from clinical trials and systematic reviews highlight that most patients with COVID-19 have decreased vitamin D levels and low levels of vitamin D increase the risk of severe disease. This evidence seems to be also confirmed in the pediatric population. CONCLUSIONS: further studies (systematic review and meta-analysis) conducted on children are needed to confirm that vitamin D affects COVID-19 outcomes and to determine the effectiveness of supplementation and the appropriate dose, duration and mode of administration. Published by Elsevier B.V. 2022-12 2022-10-14 /pmc/articles/PMC9562619/ /pubmed/36268528 http://dx.doi.org/10.1016/j.phanu.2022.100319 Text en © 2022 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Miraglia del Giudice, Michele
Indolfi, Cristiana
Dinardo, Giulio
Decimo, Fabio
Decimo, Alberto
Klain, Angela
Vitamin D status can affect COVID-19 outcomes also in pediatric population
title Vitamin D status can affect COVID-19 outcomes also in pediatric population
title_full Vitamin D status can affect COVID-19 outcomes also in pediatric population
title_fullStr Vitamin D status can affect COVID-19 outcomes also in pediatric population
title_full_unstemmed Vitamin D status can affect COVID-19 outcomes also in pediatric population
title_short Vitamin D status can affect COVID-19 outcomes also in pediatric population
title_sort vitamin d status can affect covid-19 outcomes also in pediatric population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562619/
https://www.ncbi.nlm.nih.gov/pubmed/36268528
http://dx.doi.org/10.1016/j.phanu.2022.100319
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