Dose optimisation and scarce resource allocation: two sides of the same coin

OBJECTIVE: A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines. SUMMARY OF KEY DATA: The vast majority of drug development and repurposing during the COVID-19 pandemic –...

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Autores principales: Strohbehn, Garth, Persad, Govind, Parker, William F, Murthy, Srinivas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Global Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562718/
https://www.ncbi.nlm.nih.gov/pubmed/36223969
http://dx.doi.org/10.1136/bmjopen-2022-063436
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author Strohbehn, Garth
Persad, Govind
Parker, William F
Murthy, Srinivas
author_facet Strohbehn, Garth
Persad, Govind
Parker, William F
Murthy, Srinivas
author_sort Strohbehn, Garth
collection PubMed
description OBJECTIVE: A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines. SUMMARY OF KEY DATA: The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it. CONCLUSIONS: Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values.
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spelling pubmed-95627182022-10-15 Dose optimisation and scarce resource allocation: two sides of the same coin Strohbehn, Garth Persad, Govind Parker, William F Murthy, Srinivas BMJ Open Global Health OBJECTIVE: A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines. SUMMARY OF KEY DATA: The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it. CONCLUSIONS: Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values. BMJ Publishing Group 2022-10-12 /pmc/articles/PMC9562718/ /pubmed/36223969 http://dx.doi.org/10.1136/bmjopen-2022-063436 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Global Health
Strohbehn, Garth
Persad, Govind
Parker, William F
Murthy, Srinivas
Dose optimisation and scarce resource allocation: two sides of the same coin
title Dose optimisation and scarce resource allocation: two sides of the same coin
title_full Dose optimisation and scarce resource allocation: two sides of the same coin
title_fullStr Dose optimisation and scarce resource allocation: two sides of the same coin
title_full_unstemmed Dose optimisation and scarce resource allocation: two sides of the same coin
title_short Dose optimisation and scarce resource allocation: two sides of the same coin
title_sort dose optimisation and scarce resource allocation: two sides of the same coin
topic Global Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562718/
https://www.ncbi.nlm.nih.gov/pubmed/36223969
http://dx.doi.org/10.1136/bmjopen-2022-063436
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AT parkerwilliamf doseoptimisationandscarceresourceallocationtwosidesofthesamecoin
AT murthysrinivas doseoptimisationandscarceresourceallocationtwosidesofthesamecoin

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