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Trends in the hospital-sector consumption of the WHO AWaRe Reserve group antibiotics in EU/EEA countries and the United Kingdom, 2010 to 2018
BACKGROUND: In 2019, the World Health Organization published the 21(st) Model list of Essential Medicines and updated the Access, Watch Reserve (AWaRe) antibiotics classification to improve metrics and indicators for antibiotic stewardship activities. Reserve antibiotics are regarded as last-resort...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562808/ https://www.ncbi.nlm.nih.gov/pubmed/36239173 http://dx.doi.org/10.2807/1560-7917.ES.2022.27.41.2101058 |
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author | Benkő, Ria Matuz, Mária Pető, Zoltán Weist, Klaus Heuer, Ole Vlahović-Palčevski, Vera Monnet, Dominique L Galistiani, Githa Fungie Blix, Hege Salvesen Soós, Gyöngyvér Hajdú, Edit Weist, Klaus Heuer, Ole Monnet, Dominique L. Benkő, Ria Matuz, Mária Galistiani, Githa Fungie Soós, Gyöngyvér Pető, Zoltán Hajdu, Edit Blix, Hege Salvesen Vlahović-Palčevskih, Vera Vandael, Eline Sabtcheva, Stefana Payerl-Pal, Marina Sönksen, Ute Wolff Linask, Elviira Sarvikivi, Emmi Cavalié, Philippe Schweickert, Birgitta Kontopidou, Flora Hajdú, Ágnes Oza, Ajay Fortinguerra, Filomena Seilis, Andis Kuklytė, Jolanta Bruch, Marcel Zarb, Peter Natsch, Stephanie Olczak-Pieńkowska, Anna Silva, Ana Tesař, Tomáš Cižman, Milan Hellman, Jenny Hopkins, Susan |
author_facet | Benkő, Ria Matuz, Mária Pető, Zoltán Weist, Klaus Heuer, Ole Vlahović-Palčevski, Vera Monnet, Dominique L Galistiani, Githa Fungie Blix, Hege Salvesen Soós, Gyöngyvér Hajdú, Edit Weist, Klaus Heuer, Ole Monnet, Dominique L. Benkő, Ria Matuz, Mária Galistiani, Githa Fungie Soós, Gyöngyvér Pető, Zoltán Hajdu, Edit Blix, Hege Salvesen Vlahović-Palčevskih, Vera Vandael, Eline Sabtcheva, Stefana Payerl-Pal, Marina Sönksen, Ute Wolff Linask, Elviira Sarvikivi, Emmi Cavalié, Philippe Schweickert, Birgitta Kontopidou, Flora Hajdú, Ágnes Oza, Ajay Fortinguerra, Filomena Seilis, Andis Kuklytė, Jolanta Bruch, Marcel Zarb, Peter Natsch, Stephanie Olczak-Pieńkowska, Anna Silva, Ana Tesař, Tomáš Cižman, Milan Hellman, Jenny Hopkins, Susan |
author_sort | Benkő, Ria |
collection | PubMed |
description | BACKGROUND: In 2019, the World Health Organization published the 21(st) Model list of Essential Medicines and updated the Access, Watch Reserve (AWaRe) antibiotics classification to improve metrics and indicators for antibiotic stewardship activities. Reserve antibiotics are regarded as last-resort treatment options. AIM: We investigated hospital-sector consumption quantities and trends of Reserve group antibiotics in European Union/European Economic Area countries and the United Kingdom (EU/EEA/UK). METHODS: Hospital-sector antimicrobial consumption data for 2010–2018 were obtained from the European Centre for Disease Prevention and Control. Antibacterials’ consumption for systemic use (Anatomical Therapeutic Chemical classification (ATC) group J01) were included in the analysis and expressed as defined daily doses (DDD) per 1,000 inhabitants per day. We defined reserve antibiotics as per AWaRe classification and applied linear regression to analyse trends in consumption of reserve antibiotics throughout the study period. RESULTS: EU/EEA/UK average hospital-sector reserve-antibiotic consumption increased from 0.017 to 0.050 DDD per 1,000 inhabitants per day over the study period (p = 0.002). This significant increase concerned 15 countries. In 2018, four antibiotics (tigecycline, colistin, linezolid and daptomycin) constituted 91% of the consumption. Both absolute and relative (% of total hospital sector) consumption of reserve antibiotics varied considerably (up to 42-fold) between countries (from 0.004 to 0.155 DDD per 1,000 inhabitants per day and from 0.2% to 9.3%, respectively). CONCLUSION: An increasing trend in reserve antibiotic consumption was found in Europe. The substantial variation between countries may reflect the burden of infection with multidrug-resistant bacteria. Our results could guide national actions or optimisation of reserve antibiotic use. |
format | Online Article Text |
id | pubmed-9562808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | European Centre for Disease Prevention and Control (ECDC) |
record_format | MEDLINE/PubMed |
spelling | pubmed-95628082022-10-27 Trends in the hospital-sector consumption of the WHO AWaRe Reserve group antibiotics in EU/EEA countries and the United Kingdom, 2010 to 2018 Benkő, Ria Matuz, Mária Pető, Zoltán Weist, Klaus Heuer, Ole Vlahović-Palčevski, Vera Monnet, Dominique L Galistiani, Githa Fungie Blix, Hege Salvesen Soós, Gyöngyvér Hajdú, Edit Weist, Klaus Heuer, Ole Monnet, Dominique L. Benkő, Ria Matuz, Mária Galistiani, Githa Fungie Soós, Gyöngyvér Pető, Zoltán Hajdu, Edit Blix, Hege Salvesen Vlahović-Palčevskih, Vera Vandael, Eline Sabtcheva, Stefana Payerl-Pal, Marina Sönksen, Ute Wolff Linask, Elviira Sarvikivi, Emmi Cavalié, Philippe Schweickert, Birgitta Kontopidou, Flora Hajdú, Ágnes Oza, Ajay Fortinguerra, Filomena Seilis, Andis Kuklytė, Jolanta Bruch, Marcel Zarb, Peter Natsch, Stephanie Olczak-Pieńkowska, Anna Silva, Ana Tesař, Tomáš Cižman, Milan Hellman, Jenny Hopkins, Susan Euro Surveill Research BACKGROUND: In 2019, the World Health Organization published the 21(st) Model list of Essential Medicines and updated the Access, Watch Reserve (AWaRe) antibiotics classification to improve metrics and indicators for antibiotic stewardship activities. Reserve antibiotics are regarded as last-resort treatment options. AIM: We investigated hospital-sector consumption quantities and trends of Reserve group antibiotics in European Union/European Economic Area countries and the United Kingdom (EU/EEA/UK). METHODS: Hospital-sector antimicrobial consumption data for 2010–2018 were obtained from the European Centre for Disease Prevention and Control. Antibacterials’ consumption for systemic use (Anatomical Therapeutic Chemical classification (ATC) group J01) were included in the analysis and expressed as defined daily doses (DDD) per 1,000 inhabitants per day. We defined reserve antibiotics as per AWaRe classification and applied linear regression to analyse trends in consumption of reserve antibiotics throughout the study period. RESULTS: EU/EEA/UK average hospital-sector reserve-antibiotic consumption increased from 0.017 to 0.050 DDD per 1,000 inhabitants per day over the study period (p = 0.002). This significant increase concerned 15 countries. In 2018, four antibiotics (tigecycline, colistin, linezolid and daptomycin) constituted 91% of the consumption. Both absolute and relative (% of total hospital sector) consumption of reserve antibiotics varied considerably (up to 42-fold) between countries (from 0.004 to 0.155 DDD per 1,000 inhabitants per day and from 0.2% to 9.3%, respectively). CONCLUSION: An increasing trend in reserve antibiotic consumption was found in Europe. The substantial variation between countries may reflect the burden of infection with multidrug-resistant bacteria. Our results could guide national actions or optimisation of reserve antibiotic use. European Centre for Disease Prevention and Control (ECDC) 2022-10-13 /pmc/articles/PMC9562808/ /pubmed/36239173 http://dx.doi.org/10.2807/1560-7917.ES.2022.27.41.2101058 Text en This article is copyright of the authors or their affiliated institutions, 2022. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
spellingShingle | Research Benkő, Ria Matuz, Mária Pető, Zoltán Weist, Klaus Heuer, Ole Vlahović-Palčevski, Vera Monnet, Dominique L Galistiani, Githa Fungie Blix, Hege Salvesen Soós, Gyöngyvér Hajdú, Edit Weist, Klaus Heuer, Ole Monnet, Dominique L. Benkő, Ria Matuz, Mária Galistiani, Githa Fungie Soós, Gyöngyvér Pető, Zoltán Hajdu, Edit Blix, Hege Salvesen Vlahović-Palčevskih, Vera Vandael, Eline Sabtcheva, Stefana Payerl-Pal, Marina Sönksen, Ute Wolff Linask, Elviira Sarvikivi, Emmi Cavalié, Philippe Schweickert, Birgitta Kontopidou, Flora Hajdú, Ágnes Oza, Ajay Fortinguerra, Filomena Seilis, Andis Kuklytė, Jolanta Bruch, Marcel Zarb, Peter Natsch, Stephanie Olczak-Pieńkowska, Anna Silva, Ana Tesař, Tomáš Cižman, Milan Hellman, Jenny Hopkins, Susan Trends in the hospital-sector consumption of the WHO AWaRe Reserve group antibiotics in EU/EEA countries and the United Kingdom, 2010 to 2018 |
title | Trends in the hospital-sector consumption of the WHO AWaRe Reserve group antibiotics in EU/EEA countries and the United Kingdom, 2010 to 2018 |
title_full | Trends in the hospital-sector consumption of the WHO AWaRe Reserve group antibiotics in EU/EEA countries and the United Kingdom, 2010 to 2018 |
title_fullStr | Trends in the hospital-sector consumption of the WHO AWaRe Reserve group antibiotics in EU/EEA countries and the United Kingdom, 2010 to 2018 |
title_full_unstemmed | Trends in the hospital-sector consumption of the WHO AWaRe Reserve group antibiotics in EU/EEA countries and the United Kingdom, 2010 to 2018 |
title_short | Trends in the hospital-sector consumption of the WHO AWaRe Reserve group antibiotics in EU/EEA countries and the United Kingdom, 2010 to 2018 |
title_sort | trends in the hospital-sector consumption of the who aware reserve group antibiotics in eu/eea countries and the united kingdom, 2010 to 2018 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562808/ https://www.ncbi.nlm.nih.gov/pubmed/36239173 http://dx.doi.org/10.2807/1560-7917.ES.2022.27.41.2101058 |
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