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Next Generation Immuno-Oncology Strategies: Unleashing NK Cells Activity

In recent years, immunotherapy has become a powerful therapeutic option against multiple malignancies. The unique capacity of natural killer (NK) cells to attack cancer cells without antigen specificity makes them an optimal immunotherapeutic tool for targeting tumors. Several approaches are current...

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Autores principales: Mendoza-Valderrey, Alberto, Alvarez, Maite, De Maria, Andrea, Margolin, Kim, Melero, Ignacio, Ascierto, Maria Libera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562848/
https://www.ncbi.nlm.nih.gov/pubmed/36231109
http://dx.doi.org/10.3390/cells11193147
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author Mendoza-Valderrey, Alberto
Alvarez, Maite
De Maria, Andrea
Margolin, Kim
Melero, Ignacio
Ascierto, Maria Libera
author_facet Mendoza-Valderrey, Alberto
Alvarez, Maite
De Maria, Andrea
Margolin, Kim
Melero, Ignacio
Ascierto, Maria Libera
author_sort Mendoza-Valderrey, Alberto
collection PubMed
description In recent years, immunotherapy has become a powerful therapeutic option against multiple malignancies. The unique capacity of natural killer (NK) cells to attack cancer cells without antigen specificity makes them an optimal immunotherapeutic tool for targeting tumors. Several approaches are currently being pursued to maximize the anti-tumor properties of NK cells in the clinic, including the development of NK cell expansion protocols for adoptive transfer, the establishment of a favorable microenvironment for NK cell activity, the redirection of NK cell activity against tumor cells, and the blockage of inhibitory mechanisms that constrain NK cell function. We here summarize the recent strategies in NK cell-based immunotherapies and discuss the requirement to further optimize these approaches for enhancement of the clinical outcome of NK cell-based immunotherapy targeting tumors.
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spelling pubmed-95628482022-10-15 Next Generation Immuno-Oncology Strategies: Unleashing NK Cells Activity Mendoza-Valderrey, Alberto Alvarez, Maite De Maria, Andrea Margolin, Kim Melero, Ignacio Ascierto, Maria Libera Cells Review In recent years, immunotherapy has become a powerful therapeutic option against multiple malignancies. The unique capacity of natural killer (NK) cells to attack cancer cells without antigen specificity makes them an optimal immunotherapeutic tool for targeting tumors. Several approaches are currently being pursued to maximize the anti-tumor properties of NK cells in the clinic, including the development of NK cell expansion protocols for adoptive transfer, the establishment of a favorable microenvironment for NK cell activity, the redirection of NK cell activity against tumor cells, and the blockage of inhibitory mechanisms that constrain NK cell function. We here summarize the recent strategies in NK cell-based immunotherapies and discuss the requirement to further optimize these approaches for enhancement of the clinical outcome of NK cell-based immunotherapy targeting tumors. MDPI 2022-10-06 /pmc/articles/PMC9562848/ /pubmed/36231109 http://dx.doi.org/10.3390/cells11193147 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mendoza-Valderrey, Alberto
Alvarez, Maite
De Maria, Andrea
Margolin, Kim
Melero, Ignacio
Ascierto, Maria Libera
Next Generation Immuno-Oncology Strategies: Unleashing NK Cells Activity
title Next Generation Immuno-Oncology Strategies: Unleashing NK Cells Activity
title_full Next Generation Immuno-Oncology Strategies: Unleashing NK Cells Activity
title_fullStr Next Generation Immuno-Oncology Strategies: Unleashing NK Cells Activity
title_full_unstemmed Next Generation Immuno-Oncology Strategies: Unleashing NK Cells Activity
title_short Next Generation Immuno-Oncology Strategies: Unleashing NK Cells Activity
title_sort next generation immuno-oncology strategies: unleashing nk cells activity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562848/
https://www.ncbi.nlm.nih.gov/pubmed/36231109
http://dx.doi.org/10.3390/cells11193147
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