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The role of complement in nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of chronic liver diseases globally. NAFLD includes a range of hepatic manifestations, starting with liver steatosis and potentially evolving towards nonalcoholic steatohepatitis, cirrhosis or even hepatocellular carcinoma. Although...

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Autores principales: Guo, Zhenya, Fan, Xiude, Yao, Jianni, Tomlinson, Stephen, Yuan, Guandou, He, Songqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562907/
https://www.ncbi.nlm.nih.gov/pubmed/36248852
http://dx.doi.org/10.3389/fimmu.2022.1017467
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author Guo, Zhenya
Fan, Xiude
Yao, Jianni
Tomlinson, Stephen
Yuan, Guandou
He, Songqing
author_facet Guo, Zhenya
Fan, Xiude
Yao, Jianni
Tomlinson, Stephen
Yuan, Guandou
He, Songqing
author_sort Guo, Zhenya
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of chronic liver diseases globally. NAFLD includes a range of hepatic manifestations, starting with liver steatosis and potentially evolving towards nonalcoholic steatohepatitis, cirrhosis or even hepatocellular carcinoma. Although the pathogenesis of NAFLD is incompletely understood, insulin resistance and lipid metabolism disorder are implicated. The complement system is an essential part of the immune system, but it is also involved in lipid metabolism. In particular, activation of the alternative complement pathway and the production of complement activation products such as C3a, C3adesArg (acylation stimulating protein or ASP) and C5a, are strongly associated with insulin resistance, lipid metabolism disorder, and hepatic inflammation. In this review, we briefly summarize research on the role of the complement system in NAFLD, aiming to provide a basis for the development of novel therapeutic strategies for NAFLD.
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spelling pubmed-95629072022-10-15 The role of complement in nonalcoholic fatty liver disease Guo, Zhenya Fan, Xiude Yao, Jianni Tomlinson, Stephen Yuan, Guandou He, Songqing Front Immunol Immunology Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of chronic liver diseases globally. NAFLD includes a range of hepatic manifestations, starting with liver steatosis and potentially evolving towards nonalcoholic steatohepatitis, cirrhosis or even hepatocellular carcinoma. Although the pathogenesis of NAFLD is incompletely understood, insulin resistance and lipid metabolism disorder are implicated. The complement system is an essential part of the immune system, but it is also involved in lipid metabolism. In particular, activation of the alternative complement pathway and the production of complement activation products such as C3a, C3adesArg (acylation stimulating protein or ASP) and C5a, are strongly associated with insulin resistance, lipid metabolism disorder, and hepatic inflammation. In this review, we briefly summarize research on the role of the complement system in NAFLD, aiming to provide a basis for the development of novel therapeutic strategies for NAFLD. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9562907/ /pubmed/36248852 http://dx.doi.org/10.3389/fimmu.2022.1017467 Text en Copyright © 2022 Guo, Fan, Yao, Tomlinson, Yuan and He https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Guo, Zhenya
Fan, Xiude
Yao, Jianni
Tomlinson, Stephen
Yuan, Guandou
He, Songqing
The role of complement in nonalcoholic fatty liver disease
title The role of complement in nonalcoholic fatty liver disease
title_full The role of complement in nonalcoholic fatty liver disease
title_fullStr The role of complement in nonalcoholic fatty liver disease
title_full_unstemmed The role of complement in nonalcoholic fatty liver disease
title_short The role of complement in nonalcoholic fatty liver disease
title_sort role of complement in nonalcoholic fatty liver disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562907/
https://www.ncbi.nlm.nih.gov/pubmed/36248852
http://dx.doi.org/10.3389/fimmu.2022.1017467
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