Cargando…

Phosphoproteomic Analysis Identifies TYRO3 as a Mediator of Sunitinib Resistance in Metastatic Thymomas

SIMPLE SUMMARY: After initially responding to empiric radio-chemotherapy, most advanced thymomas and thymic carcinomas become refractory and require second-line therapies. The multi-target tyrosine kinase inhibitor, sunitinib, is one of few options, especially in patients with thymic carcinomas, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Küffer, Stefan, Grabowski, Jessica, Okada, Satoru, Sojka, Nikolai, Welter, Stefan, von Hammerstein-Equord, Alexander, Hinterthaner, Marc, Cordes, Lucia, von Hahn, Xenia, Müller, Denise, Sauer, Christian, Bohnenberger, Hanibal, Marx, Alexander, Ströbel, Philipp
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562918/ https://www.ncbi.nlm.nih.gov/pubmed/36230684 http://dx.doi.org/10.3390/cancers14194762

Ejemplares similares

Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas
por: Müller, Denise, et al.
Publicado: (2021)

One carbon metabolism in human lung cancer
por: Yao, Sha, et al.
Publicado: (2021)

Role of Annexin A1 in Squamous Cell Lung Cancer Progression
por: Elakad, Omar, et al.
Publicado: (2021)

Regulation and Therapeutic Targeting of MTHFD2 and EZH2 in KRAS-Mutated Human Pulmonary Adenocarcinoma
por: Li, Yuchan, et al.
Publicado: (2022)

Expression and prognostic impact of CD49b in human lung cancer
por: Tirilomi, Anna, et al.
Publicado: (2022)

Expression and prognostic impact of DNA-PK in human lung cancer
por: Tirilomi, Anna, et al.
Publicado: (2023)

Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer
por: Elakad, Omar, et al.
Publicado: (2022)

Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer
por: Elakad, Omar, et al.
Publicado: (2020)

Enhancer of Zeste Homolog 2 (EZH2) Is a Marker of High-Grade Neuroendocrine Neoplasia in Gastroenteropancreatic and Pulmonary Tract and Predicts Poor Prognosis
por: Bremer, Sebastian C. B., et al.
Publicado: (2022)

Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry
por: Richter, Annika, et al.
Publicado: (2021)

Surgical approaches for treatment of ureteropelvic junction obstruction – a systematic review and network meta-analysis
por: Uhlig, Annemarie, et al.
Publicado: (2019)

Recent advances and conceptual changes in the classification of neuroendocrine tumors of the thymus
por: Bohnenberger, Hanibal, et al.
Publicado: (2021)

DNA-Methylation Analysis as a Tool for Thymoma Classification
por: Gaiser, Timo, et al.
Publicado: (2022)

Osteosyntheseverfahren bei Thoraxwandinstabilität
por: Spering, Christopher, et al.
Publicado: (2020)

Expression and prognostic impact of alpha thalassemia/mental retardation X-linked and death domain-associated protein in human lung cancer
por: Buentzel, Judith, et al.
Publicado: (2019)

Conductive heating mattress leads to ECG changes that mimic pacemaker spikes
por: Bräuer, A., et al.
Publicado: (2020)

Insulin‐like growth factor 2 expression in prostate cancer is regulated by promoter‐specific methylation
por: Küffer, Stefan, et al.
Publicado: (2018)

Thymoma Associated Myasthenia Gravis (TAMG): Differential Expression of Functional Pathways in Relation to MG Status in Different Thymoma Histotypes
por: Yamada, Yosuke, et al.
Publicado: (2020)

Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines
por: Bremmer, Felix, et al.
Publicado: (2019)

Urokinase-Type Plasminogen Activator Receptor (uPAR) Cooperates with Mutated KRAS in Regulating Cellular Plasticity and Gemcitabine Response in Pancreatic Adenocarcinomas
por: Peng, Luogen, et al.
Publicado: (2023)

Juan Rosai as master of our comprehensive understanding of thymus and thymoma
por: Marino, Mirella, et al.
Publicado: (2021)

Characterizing the mutational burden, DNA methylation landscape, and proteome of germ cell tumor-related somatic-type malignancies to identify the tissue-of-origin, mechanisms of therapy resistance, and druggable targets
por: Bremmer, Felix, et al.
Publicado: (2023)

Molecular pathology of thymomas: implications for diagnosis and therapy
por: Marx, Alexander, et al.
Publicado: (2021)

GTF2I Mutation in Thymomas: Independence From Racial-Ethnic Backgrounds. An Indian/German Comparative Study
por: Jain, Deepali, et al.
Publicado: (2021)

The Impact of Thymoma Histotype on Prognosis in a Worldwide Database
por: Weis, Cleo-Aron, et al.
Publicado: (2015)

A thymoma or not a thymoma—that is the question: a case report
por: Szolkowska, Malgorzata, et al.
Publicado: (2021)

Sunitinib in metastatic thymic carcinomas: Laboratory findings and initial clinical experience
por: Ströbel, P, et al.
Publicado: (2010)

TAM receptors Tyro3 and Mer as novel targets in colorectal cancer
por: Schmitz, Robin, et al.
Publicado: (2016)

Schumann resonance for tyros: essentials of global electromagnetic resonance in the Earth-ionosphere cavity
por: Nickolaenko, Alexander, et al.
Publicado: (2014)

Regulation of bone homeostasis by MERTK and TYRO3
por: Engelmann, Janik, et al.
Publicado: (2022)

TYRO3 agonist as therapy for glomerular disease
por: Zhong, Fang, et al.
Publicado: (2023)

cFLIP overexpression in T cells in thymoma-associated myasthenia gravis
por: Belharazem, Djeda, et al.
Publicado: (2015)

Tyro3 Modulates Mertk-Associated Retinal Degeneration
por: Vollrath, Douglas, et al.
Publicado: (2015)

A Few Thoughts on Professional Qualifications, for Dental Tyros
Publicado: (1856)

Instructions to a Tyro on the Use and Application of the Forceps in Midwifery
Publicado: (1820)

The Emerging Role of TYRO3 as a Therapeutic Target in Cancer
por: Smart, Sherri K., et al.
Publicado: (2018)

Classification and staging of thymoma
por: Markowiak, Till, et al.
Publicado: (2020)

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
por: Bohnenberger, Hanibal, et al.
Publicado: (2015)

Tumor Drug Concentration and Phosphoproteomic Profiles After Two Weeks of Treatment With Sunitinib in Patients with Newly Diagnosed Glioblastoma
por: van Linde, Myra E., et al.
Publicado: (2022)

The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation
por: Kim, Dennis Y., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_carpendbsakph5d0l9r8dghrd9