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Psychopathological networks in psychosis and changes over time: A long-term cohort study of first-episode psychosis

INTRODUCTION: First-episode psychosis is a critical period for early interventions to reduce the risk of poor outcomes and relapse as much as possible. There are now many studies revealing the patterns of course in the short and medium terms, but uncertainties about the long-term outcomes of symptom...

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Autores principales: Gil-Berrozpe, G., Peralta, V., Sánchez-Torres, A., Moreno-Izco, L., Garcia De Jalon, E., Peralta, D., Janda, L., Cuesta, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562945/
http://dx.doi.org/10.1192/j.eurpsy.2022.637
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author Gil-Berrozpe, G.
Peralta, V.
Sánchez-Torres, A.
Moreno-Izco, L.
Garcia De Jalon, E.
Peralta, D.
Janda, L.
Cuesta, M.
author_facet Gil-Berrozpe, G.
Peralta, V.
Sánchez-Torres, A.
Moreno-Izco, L.
Garcia De Jalon, E.
Peralta, D.
Janda, L.
Cuesta, M.
author_sort Gil-Berrozpe, G.
collection PubMed
description INTRODUCTION: First-episode psychosis is a critical period for early interventions to reduce the risk of poor outcomes and relapse as much as possible. There are now many studies revealing the patterns of course in the short and medium terms, but uncertainties about the long-term outcomes of symptomatology remain to be ascertained. OBJECTIVES: First, we ascertained whether the structure of psychopathological symptoms, dimensions and domains of psychopathology remains invariant over time between first-episode psychosis and long-term follow-up. Second, we analysed the changes in the interrelationships of psychopathological symptoms, dimensions and domains of psychopathology between FEP and long-term follow-up at three levels. METHODS: We performed network analysis to investigate first-episode and long-term stages of psychosis at three levels of analysis: micro, meso and macro. The sample was a cohort of 510 patients with first-episode psychoses from the SEGPEP study, who were reassessed at the long-term follow-up (n = 243). We used the Comprehensive Assessment of Symptoms and History (CASH) for their assessments. RESULTS: Our results showed a similar pattern of clustering between first episodes and long-term follow-up in seven psychopathological dimensions at the micro level, 3 and 4 dimensions at the meso level, and one at the macro level. They also revealed significant differences between first-episode and long-term network structure and centrality measures at the three levels. CONCLUSIONS: Our findings suggest that disorganization symptoms have more influence in long-term stabilized patients. The main results of the current study add evidence to the hierarchical, dimensional and longitudinal structuring of first-episode psychoses. DISCLOSURE: No significant relationships.
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spelling pubmed-95629452022-10-17 Psychopathological networks in psychosis and changes over time: A long-term cohort study of first-episode psychosis Gil-Berrozpe, G. Peralta, V. Sánchez-Torres, A. Moreno-Izco, L. Garcia De Jalon, E. Peralta, D. Janda, L. Cuesta, M. Eur Psychiatry Abstract INTRODUCTION: First-episode psychosis is a critical period for early interventions to reduce the risk of poor outcomes and relapse as much as possible. There are now many studies revealing the patterns of course in the short and medium terms, but uncertainties about the long-term outcomes of symptomatology remain to be ascertained. OBJECTIVES: First, we ascertained whether the structure of psychopathological symptoms, dimensions and domains of psychopathology remains invariant over time between first-episode psychosis and long-term follow-up. Second, we analysed the changes in the interrelationships of psychopathological symptoms, dimensions and domains of psychopathology between FEP and long-term follow-up at three levels. METHODS: We performed network analysis to investigate first-episode and long-term stages of psychosis at three levels of analysis: micro, meso and macro. The sample was a cohort of 510 patients with first-episode psychoses from the SEGPEP study, who were reassessed at the long-term follow-up (n = 243). We used the Comprehensive Assessment of Symptoms and History (CASH) for their assessments. RESULTS: Our results showed a similar pattern of clustering between first episodes and long-term follow-up in seven psychopathological dimensions at the micro level, 3 and 4 dimensions at the meso level, and one at the macro level. They also revealed significant differences between first-episode and long-term network structure and centrality measures at the three levels. CONCLUSIONS: Our findings suggest that disorganization symptoms have more influence in long-term stabilized patients. The main results of the current study add evidence to the hierarchical, dimensional and longitudinal structuring of first-episode psychoses. DISCLOSURE: No significant relationships. Cambridge University Press 2022-09-01 /pmc/articles/PMC9562945/ http://dx.doi.org/10.1192/j.eurpsy.2022.637 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Gil-Berrozpe, G.
Peralta, V.
Sánchez-Torres, A.
Moreno-Izco, L.
Garcia De Jalon, E.
Peralta, D.
Janda, L.
Cuesta, M.
Psychopathological networks in psychosis and changes over time: A long-term cohort study of first-episode psychosis
title Psychopathological networks in psychosis and changes over time: A long-term cohort study of first-episode psychosis
title_full Psychopathological networks in psychosis and changes over time: A long-term cohort study of first-episode psychosis
title_fullStr Psychopathological networks in psychosis and changes over time: A long-term cohort study of first-episode psychosis
title_full_unstemmed Psychopathological networks in psychosis and changes over time: A long-term cohort study of first-episode psychosis
title_short Psychopathological networks in psychosis and changes over time: A long-term cohort study of first-episode psychosis
title_sort psychopathological networks in psychosis and changes over time: a long-term cohort study of first-episode psychosis
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562945/
http://dx.doi.org/10.1192/j.eurpsy.2022.637
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