Combination bromo- and extraterminal domain and poly (ADP-ribose) polymerase inhibition synergistically enhances DNA damage and inhibits neuroblastoma tumorigenesis

PURPOSE: JQ1 is a bromo- and extraterminal (BET) domain inhibitor that downregulates MYC expression and impairs the DNA damage response. Poly (ADP-ribose) polymerase (PARP) inhibitors prevent DNA damage sensing and repair. We hypothesized that JQ1 would promote a DNA repair-deficient phenotype that...

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Detalles Bibliográficos
Autores principales: Jacobson, Jillian C., Qiao, Jingbo, Clark, Rachael A., Chung, Dai H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562984/
https://www.ncbi.nlm.nih.gov/pubmed/36227363
http://dx.doi.org/10.1007/s12672-022-00563-5

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