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Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways
Atherosclerosis (AS) is a prevalent arteriosclerotic vascular disease that forms a pathological basis for coronary heart disease, stroke, and other diseases. Inflammatory and oxidative stress responses occur throughout the development of AS. Treatment for AS over the past few decades has focused on...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563010/ https://www.ncbi.nlm.nih.gov/pubmed/36249778 http://dx.doi.org/10.3389/fphar.2022.997598 |
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author | Meng, Tianwei Li, Xinghua Li, Chengjia Liu, Jiawen Chang, Hong Jiang, Nan Li, Jiarui Zhou, Yabin Liu, Zhiping |
author_facet | Meng, Tianwei Li, Xinghua Li, Chengjia Liu, Jiawen Chang, Hong Jiang, Nan Li, Jiarui Zhou, Yabin Liu, Zhiping |
author_sort | Meng, Tianwei |
collection | PubMed |
description | Atherosclerosis (AS) is a prevalent arteriosclerotic vascular disease that forms a pathological basis for coronary heart disease, stroke, and other diseases. Inflammatory and oxidative stress responses occur throughout the development of AS. Treatment for AS over the past few decades has focused on administering high-intensity statins to reduce blood lipid levels, but these inevitably damage liver and kidney function over the long term. Natural medicines are widely used to prevent and treat AS in China because of their wide range of beneficial effects, low toxicity, and minimal side effects. We searched for relevant literature over the past 5 years in databases such as PubMed using the keywords, “atherosclerosis,” “traditional Chinese medicine,” “natural medicines,” “inflammation,” and “oxidative stress.” We found that the PI3K/AKT, TLR4, JAK/STAT, Nrf2, MAPK, and NF-κB are the most relevant inflammatory and oxidative stress pathways in AS. This review summarizes studies of the natural alkaloid, flavonoid, polyphenol, saponin, and quinone pathways through which natural medicines used to treat AS. This study aimed to update and summarize progress in understanding how natural medicines treat AS via inflammatory and oxidative stress-related signaling pathways. We also planned to create an information base for the development of novel drugs for future AS treatment. |
format | Online Article Text |
id | pubmed-9563010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95630102022-10-15 Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways Meng, Tianwei Li, Xinghua Li, Chengjia Liu, Jiawen Chang, Hong Jiang, Nan Li, Jiarui Zhou, Yabin Liu, Zhiping Front Pharmacol Pharmacology Atherosclerosis (AS) is a prevalent arteriosclerotic vascular disease that forms a pathological basis for coronary heart disease, stroke, and other diseases. Inflammatory and oxidative stress responses occur throughout the development of AS. Treatment for AS over the past few decades has focused on administering high-intensity statins to reduce blood lipid levels, but these inevitably damage liver and kidney function over the long term. Natural medicines are widely used to prevent and treat AS in China because of their wide range of beneficial effects, low toxicity, and minimal side effects. We searched for relevant literature over the past 5 years in databases such as PubMed using the keywords, “atherosclerosis,” “traditional Chinese medicine,” “natural medicines,” “inflammation,” and “oxidative stress.” We found that the PI3K/AKT, TLR4, JAK/STAT, Nrf2, MAPK, and NF-κB are the most relevant inflammatory and oxidative stress pathways in AS. This review summarizes studies of the natural alkaloid, flavonoid, polyphenol, saponin, and quinone pathways through which natural medicines used to treat AS. This study aimed to update and summarize progress in understanding how natural medicines treat AS via inflammatory and oxidative stress-related signaling pathways. We also planned to create an information base for the development of novel drugs for future AS treatment. Frontiers Media S.A. 2022-09-30 /pmc/articles/PMC9563010/ /pubmed/36249778 http://dx.doi.org/10.3389/fphar.2022.997598 Text en Copyright © 2022 Meng, Li, Li, Liu, Chang, Jiang, Li, Zhou and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Meng, Tianwei Li, Xinghua Li, Chengjia Liu, Jiawen Chang, Hong Jiang, Nan Li, Jiarui Zhou, Yabin Liu, Zhiping Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways |
title | Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways |
title_full | Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways |
title_fullStr | Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways |
title_full_unstemmed | Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways |
title_short | Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways |
title_sort | natural products of traditional chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563010/ https://www.ncbi.nlm.nih.gov/pubmed/36249778 http://dx.doi.org/10.3389/fphar.2022.997598 |
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