Pro-Inflammatory Chemokines CCL5, CXCL12, and CX3CL1 Bind to and Activate Platelet Integrin αIIbβ3 in an Allosteric Manner

Activation of platelet integrin αIIbβ3, a key event for hemostasis and thrombus formation, is known to be mediated exclusively by inside-out signaling. We showed that inflammatory chemokines CX3CL1 and CXCL12 in previous studies, and CCL5 in this study, bound to the allosteric binding site (site 2)...

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Detalles Bibliográficos
Autores principales: Takada, Yoko K., Fujita, Masaaki, Takada, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563052/
https://www.ncbi.nlm.nih.gov/pubmed/36231020
http://dx.doi.org/10.3390/cells11193059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563052/
https://www.ncbi.nlm.nih.gov/pubmed/36231020
http://dx.doi.org/10.3390/cells11193059

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