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Mass Spectrometry and Machine Learning Reveal Determinants of Client Recognition by Antiamyloid Chaperones

The assembly of proteins and peptides into amyloid fibrils is causally linked to serious disorders such as Alzheimer’s disease. Multiple proteins have been shown to prevent amyloid formation in vitro and in vivo, ranging from highly specific chaperone–client pairs to completely nonspecific binding o...

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Detalles Bibliográficos
Autores principales:	Österlund, Nicklas, Vosselman, Thibault, Leppert, Axel, Gräslund, Astrid, Jörnvall, Hans, Ilag, Leopold L., Marklund, Erik G., Elofsson, Arne, Johansson, Jan, Sahin, Cagla, Landreh, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563204/ https://www.ncbi.nlm.nih.gov/pubmed/36115577 http://dx.doi.org/10.1016/j.mcpro.2022.100413

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