ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway

Pancreatic adenocarcinoma (PAAD) is one of the most aggressive digestive system tumors in the world, with a low early diagnosis rate and a high mortality. Integrin beta 5 (ITGB5) is demonstrated to be a potent tumor promoter in several carcinomas. However, it is unknown whether ITGB5 participates in...

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Autores principales: Wen, Xin, Chen, Si, Chen, Xueting, Qiu, Hui, Wang, Wei, Zhang, Nie, Liu, Wanming, Wang, Tingting, Ding, Xin, Zhang, Longzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563233/
https://www.ncbi.nlm.nih.gov/pubmed/36249018
http://dx.doi.org/10.3389/fonc.2022.887068
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author Wen, Xin
Chen, Si
Chen, Xueting
Qiu, Hui
Wang, Wei
Zhang, Nie
Liu, Wanming
Wang, Tingting
Ding, Xin
Zhang, Longzhen
author_facet Wen, Xin
Chen, Si
Chen, Xueting
Qiu, Hui
Wang, Wei
Zhang, Nie
Liu, Wanming
Wang, Tingting
Ding, Xin
Zhang, Longzhen
author_sort Wen, Xin
collection PubMed
description Pancreatic adenocarcinoma (PAAD) is one of the most aggressive digestive system tumors in the world, with a low early diagnosis rate and a high mortality. Integrin beta 5 (ITGB5) is demonstrated to be a potent tumor promoter in several carcinomas. However, it is unknown whether ITGB5 participates in the occurrence and development of PAAD. In this study, we confirmed a high expression of ITGB5 in PAAD and its role in promoting invasiveness and transitivity in PAAD. Besides, the knockdown of ITGB5 increased cell sensitivity to radiation by promoting DNA damage repair and the MEK/ERK signaling pathway. Collectively, these results show that ITGB5 plays an essential role in pancreatic cancer growth and survival.
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spelling pubmed-95632332022-10-15 ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway Wen, Xin Chen, Si Chen, Xueting Qiu, Hui Wang, Wei Zhang, Nie Liu, Wanming Wang, Tingting Ding, Xin Zhang, Longzhen Front Oncol Oncology Pancreatic adenocarcinoma (PAAD) is one of the most aggressive digestive system tumors in the world, with a low early diagnosis rate and a high mortality. Integrin beta 5 (ITGB5) is demonstrated to be a potent tumor promoter in several carcinomas. However, it is unknown whether ITGB5 participates in the occurrence and development of PAAD. In this study, we confirmed a high expression of ITGB5 in PAAD and its role in promoting invasiveness and transitivity in PAAD. Besides, the knockdown of ITGB5 increased cell sensitivity to radiation by promoting DNA damage repair and the MEK/ERK signaling pathway. Collectively, these results show that ITGB5 plays an essential role in pancreatic cancer growth and survival. Frontiers Media S.A. 2022-09-30 /pmc/articles/PMC9563233/ /pubmed/36249018 http://dx.doi.org/10.3389/fonc.2022.887068 Text en Copyright © 2022 Wen, Chen, Chen, Qiu, Wang, Zhang, Liu, Wang, Ding and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wen, Xin
Chen, Si
Chen, Xueting
Qiu, Hui
Wang, Wei
Zhang, Nie
Liu, Wanming
Wang, Tingting
Ding, Xin
Zhang, Longzhen
ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway
title ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway
title_full ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway
title_fullStr ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway
title_full_unstemmed ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway
title_short ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway
title_sort itgb5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting dna damage repair and the mek/erk signaling pathway
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563233/
https://www.ncbi.nlm.nih.gov/pubmed/36249018
http://dx.doi.org/10.3389/fonc.2022.887068
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