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Nucleus accumbens functional connectivity and circulating endocannabinoids levels in anorexia nervosa

INTRODUCTION: Neuroimaging findings have reported aberrant functional connectivity in brain regions involved reward system in individuals with anorexia nervosa (AN) altering hedonic processing over food. Likewise, endocannabinoids such as Anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) have been...

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Autores principales: Miranda-Olivos, R., Baenas, I., Pastor, A., Del Pino, A., Codina, E., Sánchez, I., Juaneda-Segui, A., Jimenez-Murcia, S., De La Torre, R., Soriano-Mas, C., Fernandez-Aranda, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563372/
http://dx.doi.org/10.1192/j.eurpsy.2022.269
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author Miranda-Olivos, R.
Baenas, I.
Pastor, A.
Del Pino, A.
Codina, E.
Sánchez, I.
Juaneda-Segui, A.
Jimenez-Murcia, S.
De La Torre, R.
Soriano-Mas, C.
Fernandez-Aranda, F.
author_facet Miranda-Olivos, R.
Baenas, I.
Pastor, A.
Del Pino, A.
Codina, E.
Sánchez, I.
Juaneda-Segui, A.
Jimenez-Murcia, S.
De La Torre, R.
Soriano-Mas, C.
Fernandez-Aranda, F.
author_sort Miranda-Olivos, R.
collection PubMed
description INTRODUCTION: Neuroimaging findings have reported aberrant functional connectivity in brain regions involved reward system in individuals with anorexia nervosa (AN) altering hedonic processing over food. Likewise, endocannabinoids such as Anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) have been involved in rewarding aspects of food intake. OBJECTIVES: To identify nucleus accumbens (NAcc) functional connectivity with whole-brain comparing between individuals with AN and controls. Furthermore, in a sub-study, to explore the interaction between NAcc functional connectivity and peripheral AEA and 2-AG levels. METHODS: A total of 60 adult women (18 to 56 years of age) took part in the present study. Twenty-six individuals belonged to the AN group (BMI<18) and 34 to the HC group (BMI=18-24.99). All participants underwent functional magnetic resonance in resting-state, and blood samples were obtained in fasting. RESULTS: Negative functional connectivity was observed in the AN group compared with the control group between the NAcc and the cerebellum (pFWE<.001), between the NAcc and the insula (pFWE<.001), between the NAcc and the supramarginal gyrus (pFWE=.019), and between the NAcc and the postcentral gyrus (pFWE=.010). Analyses exploring the association between NAcc functional connectivity and peripheral endocannabinoids levels displayed altered NAcc-cerebellum functional connectivity was negatively associated with peripheral 2-AG levels in the AN group (r= -.553; p=.011). CONCLUSIONS: Understanding the interaction between the reward system and peripheral endocannabinoids in patients with AN could contribute to better elucidate the pathophysiology of this disorder. Future studies will need to further investigate the clinical and therapeutic implications of these findings in patients with AN. DISCLOSURE: No significant relationships.
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spelling pubmed-95633722022-10-17 Nucleus accumbens functional connectivity and circulating endocannabinoids levels in anorexia nervosa Miranda-Olivos, R. Baenas, I. Pastor, A. Del Pino, A. Codina, E. Sánchez, I. Juaneda-Segui, A. Jimenez-Murcia, S. De La Torre, R. Soriano-Mas, C. Fernandez-Aranda, F. Eur Psychiatry Abstract INTRODUCTION: Neuroimaging findings have reported aberrant functional connectivity in brain regions involved reward system in individuals with anorexia nervosa (AN) altering hedonic processing over food. Likewise, endocannabinoids such as Anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) have been involved in rewarding aspects of food intake. OBJECTIVES: To identify nucleus accumbens (NAcc) functional connectivity with whole-brain comparing between individuals with AN and controls. Furthermore, in a sub-study, to explore the interaction between NAcc functional connectivity and peripheral AEA and 2-AG levels. METHODS: A total of 60 adult women (18 to 56 years of age) took part in the present study. Twenty-six individuals belonged to the AN group (BMI<18) and 34 to the HC group (BMI=18-24.99). All participants underwent functional magnetic resonance in resting-state, and blood samples were obtained in fasting. RESULTS: Negative functional connectivity was observed in the AN group compared with the control group between the NAcc and the cerebellum (pFWE<.001), between the NAcc and the insula (pFWE<.001), between the NAcc and the supramarginal gyrus (pFWE=.019), and between the NAcc and the postcentral gyrus (pFWE=.010). Analyses exploring the association between NAcc functional connectivity and peripheral endocannabinoids levels displayed altered NAcc-cerebellum functional connectivity was negatively associated with peripheral 2-AG levels in the AN group (r= -.553; p=.011). CONCLUSIONS: Understanding the interaction between the reward system and peripheral endocannabinoids in patients with AN could contribute to better elucidate the pathophysiology of this disorder. Future studies will need to further investigate the clinical and therapeutic implications of these findings in patients with AN. DISCLOSURE: No significant relationships. Cambridge University Press 2022-09-01 /pmc/articles/PMC9563372/ http://dx.doi.org/10.1192/j.eurpsy.2022.269 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Miranda-Olivos, R.
Baenas, I.
Pastor, A.
Del Pino, A.
Codina, E.
Sánchez, I.
Juaneda-Segui, A.
Jimenez-Murcia, S.
De La Torre, R.
Soriano-Mas, C.
Fernandez-Aranda, F.
Nucleus accumbens functional connectivity and circulating endocannabinoids levels in anorexia nervosa
title Nucleus accumbens functional connectivity and circulating endocannabinoids levels in anorexia nervosa
title_full Nucleus accumbens functional connectivity and circulating endocannabinoids levels in anorexia nervosa
title_fullStr Nucleus accumbens functional connectivity and circulating endocannabinoids levels in anorexia nervosa
title_full_unstemmed Nucleus accumbens functional connectivity and circulating endocannabinoids levels in anorexia nervosa
title_short Nucleus accumbens functional connectivity and circulating endocannabinoids levels in anorexia nervosa
title_sort nucleus accumbens functional connectivity and circulating endocannabinoids levels in anorexia nervosa
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563372/
http://dx.doi.org/10.1192/j.eurpsy.2022.269
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