Molecular Mechanism of Ferroptosis in Orthopedic Diseases

Ferroptosis is a new iron-dependent programmed cell death process that is directly mediated by the accumulation of lipid peroxides and reactive oxygen species. Numerous studies have shown that ferroptosis is important in regulating the occurrence and development of bone-related diseases, but the und...

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Autores principales: Gao, Lu, Hua, Weizhong, Tian, Lixiang, Zhou, Xuchang, Wang, Dongxue, Yang, Yajing, Ni, Guoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563396/
https://www.ncbi.nlm.nih.gov/pubmed/36230941
http://dx.doi.org/10.3390/cells11192979
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author Gao, Lu
Hua, Weizhong
Tian, Lixiang
Zhou, Xuchang
Wang, Dongxue
Yang, Yajing
Ni, Guoxin
author_facet Gao, Lu
Hua, Weizhong
Tian, Lixiang
Zhou, Xuchang
Wang, Dongxue
Yang, Yajing
Ni, Guoxin
author_sort Gao, Lu
collection PubMed
description Ferroptosis is a new iron-dependent programmed cell death process that is directly mediated by the accumulation of lipid peroxides and reactive oxygen species. Numerous studies have shown that ferroptosis is important in regulating the occurrence and development of bone-related diseases, but the underlying mechanisms are not completely clear. Herein, we review the progress of the mechanism of ferroptosis in bone marrow injury, osteoporosis, osteoarthritis, and osteosarcoma and attempt to deeply understand the regulatory targets of ferroptosis, which will open up a new way for the prevention and treatment of orthopedic diseases.
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spelling pubmed-95633962022-10-15 Molecular Mechanism of Ferroptosis in Orthopedic Diseases Gao, Lu Hua, Weizhong Tian, Lixiang Zhou, Xuchang Wang, Dongxue Yang, Yajing Ni, Guoxin Cells Review Ferroptosis is a new iron-dependent programmed cell death process that is directly mediated by the accumulation of lipid peroxides and reactive oxygen species. Numerous studies have shown that ferroptosis is important in regulating the occurrence and development of bone-related diseases, but the underlying mechanisms are not completely clear. Herein, we review the progress of the mechanism of ferroptosis in bone marrow injury, osteoporosis, osteoarthritis, and osteosarcoma and attempt to deeply understand the regulatory targets of ferroptosis, which will open up a new way for the prevention and treatment of orthopedic diseases. MDPI 2022-09-24 /pmc/articles/PMC9563396/ /pubmed/36230941 http://dx.doi.org/10.3390/cells11192979 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gao, Lu
Hua, Weizhong
Tian, Lixiang
Zhou, Xuchang
Wang, Dongxue
Yang, Yajing
Ni, Guoxin
Molecular Mechanism of Ferroptosis in Orthopedic Diseases
title Molecular Mechanism of Ferroptosis in Orthopedic Diseases
title_full Molecular Mechanism of Ferroptosis in Orthopedic Diseases
title_fullStr Molecular Mechanism of Ferroptosis in Orthopedic Diseases
title_full_unstemmed Molecular Mechanism of Ferroptosis in Orthopedic Diseases
title_short Molecular Mechanism of Ferroptosis in Orthopedic Diseases
title_sort molecular mechanism of ferroptosis in orthopedic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563396/
https://www.ncbi.nlm.nih.gov/pubmed/36230941
http://dx.doi.org/10.3390/cells11192979
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