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STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors
Nowadays, molecular research is essential for the better understanding of tumor cells’ pathophysiology. The increasing number of neoplasms is taken under ‘the molecular magnifying glass’; therefore, it is possible to discover the complex relationships between cytophysiology and tumor cells. Signal t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563420/ https://www.ncbi.nlm.nih.gov/pubmed/36230984 http://dx.doi.org/10.3390/cells11193024 |
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author | Golus, Maciej Bugajski, Piotr Chorbińska, Joanna Krajewski, Wojciech Lemiński, Artur Saczko, Jolanta Kulbacka, Julita Szydełko, Tomasz Małkiewicz, Bartosz |
author_facet | Golus, Maciej Bugajski, Piotr Chorbińska, Joanna Krajewski, Wojciech Lemiński, Artur Saczko, Jolanta Kulbacka, Julita Szydełko, Tomasz Małkiewicz, Bartosz |
author_sort | Golus, Maciej |
collection | PubMed |
description | Nowadays, molecular research is essential for the better understanding of tumor cells’ pathophysiology. The increasing number of neoplasms is taken under ‘the molecular magnifying glass’; therefore, it is possible to discover the complex relationships between cytophysiology and tumor cells. Signal transducer and activator of transcription 3 (STAT3) belongs to the family of latent cytoplasmic transcription factors called STATs, which comprises seven members: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6. Those proteins play important role in cytokine-activated gene expression by transducing signals from the cell membrane to the nucleus. Abnormal prolonged activation results in tumorigenesis, metastasis, cell proliferation, invasion, migration, and angiogenesis. Inhibition of this transcription factor inhibits the previously mentioned effects in cancer cells, whereas normal cells are not affected. Hence, STAT3 might be a viable target for cancer therapy. |
format | Online Article Text |
id | pubmed-9563420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95634202022-10-15 STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors Golus, Maciej Bugajski, Piotr Chorbińska, Joanna Krajewski, Wojciech Lemiński, Artur Saczko, Jolanta Kulbacka, Julita Szydełko, Tomasz Małkiewicz, Bartosz Cells Review Nowadays, molecular research is essential for the better understanding of tumor cells’ pathophysiology. The increasing number of neoplasms is taken under ‘the molecular magnifying glass’; therefore, it is possible to discover the complex relationships between cytophysiology and tumor cells. Signal transducer and activator of transcription 3 (STAT3) belongs to the family of latent cytoplasmic transcription factors called STATs, which comprises seven members: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6. Those proteins play important role in cytokine-activated gene expression by transducing signals from the cell membrane to the nucleus. Abnormal prolonged activation results in tumorigenesis, metastasis, cell proliferation, invasion, migration, and angiogenesis. Inhibition of this transcription factor inhibits the previously mentioned effects in cancer cells, whereas normal cells are not affected. Hence, STAT3 might be a viable target for cancer therapy. MDPI 2022-09-27 /pmc/articles/PMC9563420/ /pubmed/36230984 http://dx.doi.org/10.3390/cells11193024 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Golus, Maciej Bugajski, Piotr Chorbińska, Joanna Krajewski, Wojciech Lemiński, Artur Saczko, Jolanta Kulbacka, Julita Szydełko, Tomasz Małkiewicz, Bartosz STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors |
title | STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors |
title_full | STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors |
title_fullStr | STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors |
title_full_unstemmed | STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors |
title_short | STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors |
title_sort | stat3 and its pathways’ dysregulation—underestimated role in urological tumors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563420/ https://www.ncbi.nlm.nih.gov/pubmed/36230984 http://dx.doi.org/10.3390/cells11193024 |
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