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STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors

Nowadays, molecular research is essential for the better understanding of tumor cells’ pathophysiology. The increasing number of neoplasms is taken under ‘the molecular magnifying glass’; therefore, it is possible to discover the complex relationships between cytophysiology and tumor cells. Signal t...

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Autores principales: Golus, Maciej, Bugajski, Piotr, Chorbińska, Joanna, Krajewski, Wojciech, Lemiński, Artur, Saczko, Jolanta, Kulbacka, Julita, Szydełko, Tomasz, Małkiewicz, Bartosz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563420/
https://www.ncbi.nlm.nih.gov/pubmed/36230984
http://dx.doi.org/10.3390/cells11193024
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author Golus, Maciej
Bugajski, Piotr
Chorbińska, Joanna
Krajewski, Wojciech
Lemiński, Artur
Saczko, Jolanta
Kulbacka, Julita
Szydełko, Tomasz
Małkiewicz, Bartosz
author_facet Golus, Maciej
Bugajski, Piotr
Chorbińska, Joanna
Krajewski, Wojciech
Lemiński, Artur
Saczko, Jolanta
Kulbacka, Julita
Szydełko, Tomasz
Małkiewicz, Bartosz
author_sort Golus, Maciej
collection PubMed
description Nowadays, molecular research is essential for the better understanding of tumor cells’ pathophysiology. The increasing number of neoplasms is taken under ‘the molecular magnifying glass’; therefore, it is possible to discover the complex relationships between cytophysiology and tumor cells. Signal transducer and activator of transcription 3 (STAT3) belongs to the family of latent cytoplasmic transcription factors called STATs, which comprises seven members: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6. Those proteins play important role in cytokine-activated gene expression by transducing signals from the cell membrane to the nucleus. Abnormal prolonged activation results in tumorigenesis, metastasis, cell proliferation, invasion, migration, and angiogenesis. Inhibition of this transcription factor inhibits the previously mentioned effects in cancer cells, whereas normal cells are not affected. Hence, STAT3 might be a viable target for cancer therapy.
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spelling pubmed-95634202022-10-15 STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors Golus, Maciej Bugajski, Piotr Chorbińska, Joanna Krajewski, Wojciech Lemiński, Artur Saczko, Jolanta Kulbacka, Julita Szydełko, Tomasz Małkiewicz, Bartosz Cells Review Nowadays, molecular research is essential for the better understanding of tumor cells’ pathophysiology. The increasing number of neoplasms is taken under ‘the molecular magnifying glass’; therefore, it is possible to discover the complex relationships between cytophysiology and tumor cells. Signal transducer and activator of transcription 3 (STAT3) belongs to the family of latent cytoplasmic transcription factors called STATs, which comprises seven members: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6. Those proteins play important role in cytokine-activated gene expression by transducing signals from the cell membrane to the nucleus. Abnormal prolonged activation results in tumorigenesis, metastasis, cell proliferation, invasion, migration, and angiogenesis. Inhibition of this transcription factor inhibits the previously mentioned effects in cancer cells, whereas normal cells are not affected. Hence, STAT3 might be a viable target for cancer therapy. MDPI 2022-09-27 /pmc/articles/PMC9563420/ /pubmed/36230984 http://dx.doi.org/10.3390/cells11193024 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Golus, Maciej
Bugajski, Piotr
Chorbińska, Joanna
Krajewski, Wojciech
Lemiński, Artur
Saczko, Jolanta
Kulbacka, Julita
Szydełko, Tomasz
Małkiewicz, Bartosz
STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors
title STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors
title_full STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors
title_fullStr STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors
title_full_unstemmed STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors
title_short STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors
title_sort stat3 and its pathways’ dysregulation—underestimated role in urological tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563420/
https://www.ncbi.nlm.nih.gov/pubmed/36230984
http://dx.doi.org/10.3390/cells11193024
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