C9-ALS-Associated Proline-Arginine Dipeptide Repeat Protein Induces Activation of NLRP3 Inflammasome of HMC3 Microglia Cells by Binding of Complement Component 1 Q Subcomponent-Binding Protein (C1QBP), and Syringin Prevents This Effect

Amyotrophic lateral sclerosis (ALS) is a fatal disease in which motor neurons gradually degenerate. The mutation of the C9orf72 gene is the main genetic cause of ALS (C9-ALS). One of its specific pathological features is the production of proline-arginine (PR) dipeptide repeat protein (DPR). In this...

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Detalles Bibliográficos
Autores principales: Fu, Ru-Huei, Tsai, Chia-Wen, Chiu, Shao-Chih, Liu, Shih-Ping, Chiang, Yu-Ting, Kuo, Yun-Hua, Shyu, Woei-Cherng, Lin, Shinn-Zong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563448/
https://www.ncbi.nlm.nih.gov/pubmed/36231090
http://dx.doi.org/10.3390/cells11193128

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