In Vivo Inhibition of miR-34a Modestly Limits Cardiac Enlargement and Fibrosis in a Mouse Model with Established Type 1 Diabetes-Induced Cardiomyopathy, but Does Not Improve Diastolic Function

MicroRNA 34a (miR-34a) is elevated in the heart in a setting of cardiac stress or pathology, and we previously reported that inhibition of miR-34a in vivo provided protection in a setting of pressure overload-induced pathological cardiac hypertrophy and dilated cardiomyopathy. Prior work had also sh...

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Detalles Bibliográficos
Autores principales: Bernardo, Bianca C., Yildiz, Gunes S., Kiriazis, Helen, Harmawan, Claudia A., Tai, Celeste M. K., Ritchie, Rebecca H., McMullen, Julie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563608/
https://www.ncbi.nlm.nih.gov/pubmed/36231079
http://dx.doi.org/10.3390/cells11193117

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