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Pharmacokinetic study of single and multiple oral administration of glutamine in healthy Beagles
Glutamine is an amino acid that is mainly used for the treatment of gastrointestinal diseases in clinic, but there is a lack of such medicine in veterinary clinic, and its research in dogs has never been seen. This study aimed to investigate the pharmacokinetics of single and multiple administration...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563617/ https://www.ncbi.nlm.nih.gov/pubmed/36249805 http://dx.doi.org/10.3389/fphar.2022.1014474 |
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author | Guo, Fanxi Liu, Dongying Zhou, Yuqing Yu, Yuanqian Xu, Yidan Zou, Yuanpeng Li, Chongyang Zhang, Fengyichi Yu, Zugong |
author_facet | Guo, Fanxi Liu, Dongying Zhou, Yuqing Yu, Yuanqian Xu, Yidan Zou, Yuanpeng Li, Chongyang Zhang, Fengyichi Yu, Zugong |
author_sort | Guo, Fanxi |
collection | PubMed |
description | Glutamine is an amino acid that is mainly used for the treatment of gastrointestinal diseases in clinic, but there is a lack of such medicine in veterinary clinic, and its research in dogs has never been seen. This study aimed to investigate the pharmacokinetics of single and multiple administration of glutamine (Gln) tablets in Beagles. Twenty-four healthy Beagles were randomly selected for the pharmacokinetic study of a single dose of low (120 mg/kg), medium (240 mg/kg), and high (360 mg/kg) Gln tablets. After 7 days of washout period, six Beagles in the medium group were selected for a multiple-dose pharmacokinetic study, 240 mg/kg twice a day for 7 days. The Gln concentration in plasma was determined by a validated UPLC-MS/MS method. The results of single oral administration of different doses of Gln tablets showed that C(max), AUC(0→t), AUC(0→∝) had a certain linear relationship with the dosage. T-tests were performed for single and multiple administration of T(max), C(max), t(1/2λz), AUC(0→t), and AUC(0→∝), and the results showed no significant differences (p > 0.05). Therefore, Gln tablets were absorbed quickly by oral administration, and there was no accumulation in Beagles after 7 days of administration. |
format | Online Article Text |
id | pubmed-9563617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95636172022-10-15 Pharmacokinetic study of single and multiple oral administration of glutamine in healthy Beagles Guo, Fanxi Liu, Dongying Zhou, Yuqing Yu, Yuanqian Xu, Yidan Zou, Yuanpeng Li, Chongyang Zhang, Fengyichi Yu, Zugong Front Pharmacol Pharmacology Glutamine is an amino acid that is mainly used for the treatment of gastrointestinal diseases in clinic, but there is a lack of such medicine in veterinary clinic, and its research in dogs has never been seen. This study aimed to investigate the pharmacokinetics of single and multiple administration of glutamine (Gln) tablets in Beagles. Twenty-four healthy Beagles were randomly selected for the pharmacokinetic study of a single dose of low (120 mg/kg), medium (240 mg/kg), and high (360 mg/kg) Gln tablets. After 7 days of washout period, six Beagles in the medium group were selected for a multiple-dose pharmacokinetic study, 240 mg/kg twice a day for 7 days. The Gln concentration in plasma was determined by a validated UPLC-MS/MS method. The results of single oral administration of different doses of Gln tablets showed that C(max), AUC(0→t), AUC(0→∝) had a certain linear relationship with the dosage. T-tests were performed for single and multiple administration of T(max), C(max), t(1/2λz), AUC(0→t), and AUC(0→∝), and the results showed no significant differences (p > 0.05). Therefore, Gln tablets were absorbed quickly by oral administration, and there was no accumulation in Beagles after 7 days of administration. Frontiers Media S.A. 2022-09-30 /pmc/articles/PMC9563617/ /pubmed/36249805 http://dx.doi.org/10.3389/fphar.2022.1014474 Text en Copyright © 2022 Guo, Liu, Zhou, Yu, Xu, Zou, Li, Zhang and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Guo, Fanxi Liu, Dongying Zhou, Yuqing Yu, Yuanqian Xu, Yidan Zou, Yuanpeng Li, Chongyang Zhang, Fengyichi Yu, Zugong Pharmacokinetic study of single and multiple oral administration of glutamine in healthy Beagles |
title | Pharmacokinetic study of single and multiple oral administration of glutamine in healthy Beagles |
title_full | Pharmacokinetic study of single and multiple oral administration of glutamine in healthy Beagles |
title_fullStr | Pharmacokinetic study of single and multiple oral administration of glutamine in healthy Beagles |
title_full_unstemmed | Pharmacokinetic study of single and multiple oral administration of glutamine in healthy Beagles |
title_short | Pharmacokinetic study of single and multiple oral administration of glutamine in healthy Beagles |
title_sort | pharmacokinetic study of single and multiple oral administration of glutamine in healthy beagles |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563617/ https://www.ncbi.nlm.nih.gov/pubmed/36249805 http://dx.doi.org/10.3389/fphar.2022.1014474 |
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