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The functional connectivity of the basal ganglia subregions changed in mid-aged and young males with chronic prostatitis/chronic pelvic pain syndrome

BACKGROUND: The Basal ganglia (BG) played a crucial role in the brain-level mechanisms of chronic pain disorders. However, the functional changes of BG in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still poorly understood. This study investigated the BG subregions’ resting-state...

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Autores principales: Lan, Xi, Niu, Xuan, Bai, Wei-Xian, Li, Hai-Ning, Zhu, Xin-Yi, Ma, Wen-Jun, Li, Jian-Long, Dun, Wang-Huan, Zhang, Ming, He, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563619/
https://www.ncbi.nlm.nih.gov/pubmed/36248695
http://dx.doi.org/10.3389/fnhum.2022.1013425
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author Lan, Xi
Niu, Xuan
Bai, Wei-Xian
Li, Hai-Ning
Zhu, Xin-Yi
Ma, Wen-Jun
Li, Jian-Long
Dun, Wang-Huan
Zhang, Ming
He, Juan
author_facet Lan, Xi
Niu, Xuan
Bai, Wei-Xian
Li, Hai-Ning
Zhu, Xin-Yi
Ma, Wen-Jun
Li, Jian-Long
Dun, Wang-Huan
Zhang, Ming
He, Juan
author_sort Lan, Xi
collection PubMed
description BACKGROUND: The Basal ganglia (BG) played a crucial role in the brain-level mechanisms of chronic pain disorders. However, the functional changes of BG in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still poorly understood. This study investigated the BG subregions’ resting-state functional connectivity (rs-FC) in CP/CPPS patients compared with healthy controls. METHODS: Twenty eight patients with CP/CPPS and 28 age- and education-matched healthy males underwent clinical measurements and 3T brain MR imaging, including T1-weighted structural images and resting-state functional imaging. The data were analyzed by the seeded-based rs-FC analysis. Then, a machine learning method was applied to assess the feasibility of detecting CP/CPPS patients through the changed rs-FC. RESULTS: Compared with healthy males, patients presented decreased rs-FC between the BG subregions and right middle cingulate cortex, and correlated with pain (r = 0.51, p-uncorrected = 0.005) and urinary symptoms (r = –0.4, p-uncorrected = 0.034). The left superior temporal gyrus and right supramarginal gyrus showed decreased rs-FC with the BG subregions as well. The area under the receiver operating characteristic curve of 0.943 (accuracy = 80%, F1-score = 80.6%) was achieved for the classification of CP/CPPS patients and healthy males with support vector machine (SVM) based on the changed rs-FC. CONCLUSION: These findings provide evidence of altered BG subregions’ rs-FC in CP/CPPS, which may contribute to our understanding of the BG’s role in CP/CPPS.
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spelling pubmed-95636192022-10-15 The functional connectivity of the basal ganglia subregions changed in mid-aged and young males with chronic prostatitis/chronic pelvic pain syndrome Lan, Xi Niu, Xuan Bai, Wei-Xian Li, Hai-Ning Zhu, Xin-Yi Ma, Wen-Jun Li, Jian-Long Dun, Wang-Huan Zhang, Ming He, Juan Front Hum Neurosci Neuroscience BACKGROUND: The Basal ganglia (BG) played a crucial role in the brain-level mechanisms of chronic pain disorders. However, the functional changes of BG in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still poorly understood. This study investigated the BG subregions’ resting-state functional connectivity (rs-FC) in CP/CPPS patients compared with healthy controls. METHODS: Twenty eight patients with CP/CPPS and 28 age- and education-matched healthy males underwent clinical measurements and 3T brain MR imaging, including T1-weighted structural images and resting-state functional imaging. The data were analyzed by the seeded-based rs-FC analysis. Then, a machine learning method was applied to assess the feasibility of detecting CP/CPPS patients through the changed rs-FC. RESULTS: Compared with healthy males, patients presented decreased rs-FC between the BG subregions and right middle cingulate cortex, and correlated with pain (r = 0.51, p-uncorrected = 0.005) and urinary symptoms (r = –0.4, p-uncorrected = 0.034). The left superior temporal gyrus and right supramarginal gyrus showed decreased rs-FC with the BG subregions as well. The area under the receiver operating characteristic curve of 0.943 (accuracy = 80%, F1-score = 80.6%) was achieved for the classification of CP/CPPS patients and healthy males with support vector machine (SVM) based on the changed rs-FC. CONCLUSION: These findings provide evidence of altered BG subregions’ rs-FC in CP/CPPS, which may contribute to our understanding of the BG’s role in CP/CPPS. Frontiers Media S.A. 2022-09-30 /pmc/articles/PMC9563619/ /pubmed/36248695 http://dx.doi.org/10.3389/fnhum.2022.1013425 Text en Copyright © 2022 Lan, Niu, Bai, Li, Zhu, Ma, Li, Dun, Zhang and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lan, Xi
Niu, Xuan
Bai, Wei-Xian
Li, Hai-Ning
Zhu, Xin-Yi
Ma, Wen-Jun
Li, Jian-Long
Dun, Wang-Huan
Zhang, Ming
He, Juan
The functional connectivity of the basal ganglia subregions changed in mid-aged and young males with chronic prostatitis/chronic pelvic pain syndrome
title The functional connectivity of the basal ganglia subregions changed in mid-aged and young males with chronic prostatitis/chronic pelvic pain syndrome
title_full The functional connectivity of the basal ganglia subregions changed in mid-aged and young males with chronic prostatitis/chronic pelvic pain syndrome
title_fullStr The functional connectivity of the basal ganglia subregions changed in mid-aged and young males with chronic prostatitis/chronic pelvic pain syndrome
title_full_unstemmed The functional connectivity of the basal ganglia subregions changed in mid-aged and young males with chronic prostatitis/chronic pelvic pain syndrome
title_short The functional connectivity of the basal ganglia subregions changed in mid-aged and young males with chronic prostatitis/chronic pelvic pain syndrome
title_sort functional connectivity of the basal ganglia subregions changed in mid-aged and young males with chronic prostatitis/chronic pelvic pain syndrome
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563619/
https://www.ncbi.nlm.nih.gov/pubmed/36248695
http://dx.doi.org/10.3389/fnhum.2022.1013425
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