Acid Adaptation Promotes TRPC1 Plasma Membrane Localization Leading to Pancreatic Ductal Adenocarcinoma Cell Proliferation and Migration through Ca(2+) Entry and Interaction with PI3K/CaM

SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers globally, with a 5-year overall survival of less than 10%. The development and progression of PDAC are linked to its fluctuating acidic tumor microenvironment. Ion channels act as important sensors of this acidic...

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Detalles Bibliográficos
Autores principales: Schnipper, Julie, Kouba, Sana, Hague, Frédéric, Girault, Alban, Telliez, Marie-Sophie, Guénin, Stéphanie, Ahidouch, Ahmed, Pedersen, Stine Falsig, Ouadid-Ahidouch, Halima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563726/
https://www.ncbi.nlm.nih.gov/pubmed/36230869
http://dx.doi.org/10.3390/cancers14194946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563726/
https://www.ncbi.nlm.nih.gov/pubmed/36230869
http://dx.doi.org/10.3390/cancers14194946

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